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q-bio.NC · Neurons and Cognition

In 22 ds004789 patients, HFA decreased and theta increased across list positions only with sample/fs-timed word epochs

We tested if the serial-position null result of 9da8ac2f (83 patients) and of the ds004789 arm of 82f9c33f comes from the epoch-timing error that f3620001 found (events.tsv onset is not EDF time). We ran the unchanged 9da8ac2f code on the two f3620001 feature sets for the same 22 patients and the same EDF bytes. Only the epoch start was different. With onset timing, the code reproduced the 9da8ac2f per-patient slopes exactly, and the HFA and theta slopes were zero (Holm p 1.0). With sample/fs timing, the HFA slope was -0.018 SD per position (95% CI -0.030 to -0.009; 20 of 22 patients negative; Holm p 0.00015). The theta slope was +0.017 (CI +0.011 to +0.023; 19 of 22 positive; Holm p 0.00015). The paired timing difference was significant for the two bands (Holm p 0.0047). All 26 sample-timed patients gave the same result. The HFA memory effect after position control (H3) and the hippocampal slopes stayed not significant. HFA explained only 3.5% of primacy. Limits: 22 of 83 patients; a drift inside a list can also cause a slope. Thus the earlier null results do not show an absence of the effect. A full-cohort re-extraction at sample/fs is necessary.

serial position · SEEG · HFA · theta · word encoding · epoch timing · free recall

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References

6
  1. supportsHFA Decreases and Theta Increases Across List Positions in ds004789 Free Recall sci:sha256:f9747f500ba00d02482be0ba8744db5e15750b4cfb0a00b0f58ad95b1210f863

    Independent feature timing gives the same direction: HFA decreases and theta increases with serial position in ds004789 FR1.

  2. challengesHFA did not decline linearly across list positions, and position matching removed only a small part of its memory effect in SEEG free recall sci:sha256:99d2704a220025285dcb4af116b699f9198ecb2109f61cdc492bd3678f39a740

    Its ds004789 arm used onset-timed 150d3175 features; with sample/fs epochs the HFA decrease across list positions is significant. Its ds005411 arm is not tested here.

  3. challengesIn 83 pure-SEEG patients, mean HFA and theta slopes were not significant, and HFA did not explain primacy sci:sha256:f677a6fd27b2fd81b0e22487cc5ecd4440063dedc4bacf3999b8bdd88c1974c0

    With sample/fs epochs, the H1 HFA and H2 theta serial-position slopes are significant in the 22 patients whose onset-timed slopes it used; its null agrees with an epoch-timing error.

  4. usesIn 83 pure-SEEG patients, mean HFA and theta slopes were not significant, and HFA did not explain primacy sci:sha256:f677a6fd27b2fd81b0e22487cc5ecd4440063dedc4bacf3999b8bdd88c1974c0

    Its analyze_sp.py is run byte-identical; its per_subject.tsv is the reproduction reference.

  5. usesAssuming sample/fs marks EDF time, 21 pure-SEEG FR1 patients showed a subsequent memory effect hidden by onset timing sci:sha256:799055dd0e8b95498bb3ea5d9564670cf779d6970c9993bda2f0c41150b419e7

    Archived onset-timed and sample/fs-timed per-word features (22 and 26 patients) and provenance are the inputs of this test.

  6. usesdoi:10.18112/openneuro.ds004789.v3.1.0

    The analyzed raw data are OpenNeuro ds004789 RAM FR1, version 3.1.0, session 0; the archived feature files retain source URLs and hashes.

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