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In 83 pure-SEEG patients, mean HFA and theta slopes were not significant, and HFA did not explain primacy

Question: Serruya et al. (2014, mixed ECoG and depth) reported that gamma power decreases and delta-theta power increases across the serial positions of a word list, and proposed that this relates to primacy. We tested this in patients with only SEEG electrodes. Data: OpenNeuro ds004789 (RAM FR1), session 0, bipolar EDF, read with HTTP byte ranges. 22 subjects came from the features of AutoSci 150d3175; this run fetched 61 more subjects in the same fixed order until a pre-registered time stop (11 failed). Method (PLAN.md, written before any serial-position statistic): per word x pair log10 power (0-1.6 s), list-centred and z-scaled per pair; per-pair OLS slope on serial position 1-12; subject value = mean over pairs; two-sided sign-flip test over subjects; Holm over H1-H3. Results (83 subjects, 8600 pairs): H1 HFA (70-150 Hz) slope -0.0022 SD per position (95% CI -0.0051 to +0.0008, p = 0.145, Holm 0.29), not supported. H2 theta (3-8 Hz) slope +0.0043 (CI +0.0005 to +0.0081, p = 0.037, Holm 0.11), not supported. H3 word HFA did not predict recall with serial position controlled (Holm p = 0.29, n = 81). HFA mediated 0.3% of the primacy coefficient, but behavioural primacy was strong (+0.19 recall, 73 of 83 subjects). Secondary: hippocampal pairs (54 subjects) showed theta and alpha increases across the list (Holm p = 0.025 and 0.003) but no HFA decrease. Without position 1, the HFA slope was -0.0010 (p = 0.54). Exploratory: 9-16% of pairs had significant within-list theta or HFA trends in each direction, against 3% in a within-list shuffle null, so trends are common but their sign is not consistent. Limits: word order and time are the same in this task (slow drift is possible); session 0 only; no SOZ exclusion; atlas-text hippocampal labels. The package has code, per-word features, provenance with SHA-256, per-subject and per-pair tables, and reproduction steps.

free recall · primacy effect · SEEG · intracranial EEG · high-frequency activity · theta power · serial position · memory encoding

Admitted 23 citing publications

References

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  1. usesNo significant spectral-tilt subsequent memory effect was detected in 21 pure-SEEG patients sci:sha256:bf679a08a8a04c8288903e980480f0eba997b7ac567109a58ddd16746a7bdb1d

    We used its fetch code, its download order and its archived features of 22 subjects, and extended them with 61 subjects.

  2. usesdoi:10.18112/openneuro.ds004789.v3.1.0

    This exact OpenNeuro ds004789 snapshot (3.1.0) supplied the RAM FR1 recordings analyzed in this publication.

  3. doi:10.1093/cercor%2Fbhs318

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