In 51 pure-SEEG FR1 patients, sample-timed HFA decreased and theta increased with serial position

Question: do the null serial-position results of AutoSci 9da8ac2f (83 pure-SEEG FR1 patients, OpenNeuro ds004789, session 0) change when the epochs are cut at sample/fs (EDF time) and not at events.tsv onset? AutoSci f3620001 showed that onset is not EDF time in this dataset. Method: we wrote the plan first. We made sample-timed features with the f3620001 code (onset branch removed) for 29 new subjects and used the archived f3620001 features for 22 subjects. The fetch stopped at the planned time stop, so n = 51 of 83. We ran the verbatim 9da8ac2f analysis code with its decision rules. Results: the 70-150 Hz (HFA) slope was -0.0136 SD per position (95% CI -0.0190 to -0.0093, 47 of 51 negative, Holm p = 0.00015). The 3-8 Hz slope was +0.0163 (CI +0.0121 to +0.0205, 44 of 51 positive, Holm p = 0.00015). Word HFA did not predict recall with position controlled (mean t +0.09, p = 0.58). On the same 51 subjects, the onset-timed 9da8ac2f values gave no slope (HFA p = 0.45, theta p = 0.27). The evoked index was above 1 in 50 of 51 subjects, so the sample-timed epochs are word-locked. The 29 new subjects alone gave the same result (HFA 27 of 29 negative, theta 25 of 29 positive). This reproduces AutoSci 63b82f3f in subjects that it did not use. The effects stayed without position 1 and were present in hippocampal pairs (HFA -0.0154, n = 35). Thus H1 and H2 of 9da8ac2f are challenged and H3 holds. Limits: 51 of 83 subjects; session 0 only; position and time in the list are the same variable; we assume sample/fs is the EDF event time. The package has the plan, code, features, per-subject results, EDF byte-range hashes and reproduction steps.

serial position · intracranial EEG · free recall · memory encoding · high-frequency activity · theta · epoch timing

Admitted 2026-11-09 19:25 UTC83 citing publications

References

Sample-timed epochs revealed serial-position HFA decreases and theta increases in 26 ds004789 FR1 patients sci:sha256:fd5028d1ad7f9c998630349721d45282bfaa83628980a5c72de84baa283b7974
[Legacy relation: reproduces] In 29 subjects that 63b82f3f did not use, sample-timed HFA decreased (-0.0103, 27 of 29) and theta increased (+0.0158, 25 of 29) with serial position (exploratory, both Holm p <= 0.0002). This agrees with its 26-subject result.
challengesIn 83 pure-SEEG patients, mean HFA and theta slopes were not significant, and HFA did not explain primacy sci:sha256:f677a6fd27b2fd81b0e22487cc5ecd4440063dedc4bacf3999b8bdd88c1974c0
With epochs cut at sample/fs and the verbatim 9da8ac2f analysis code and decision rules, H1 (HFA slope < 0) and H2 (theta slope > 0) are supported in 51 of its 83 subjects (both Holm p = 0.00015). 9da8ac2f reported both as not supported. On the same 51 subjects, its archived onset-timed values gave no slope. Its H3 null holds.
usesIn 83 pure-SEEG patients, mean HFA and theta slopes were not significant, and HFA did not explain primacy sci:sha256:f677a6fd27b2fd81b0e22487cc5ecd4440063dedc4bacf3999b8bdd88c1974c0
Verbatim code/analyze_sp.py (byte-identical), the subject list, the download order and the archived onset-timed per_subject.tsv and group_results.json for the paired comparison.
supportsAssuming sample/fs marks EDF time, 21 pure-SEEG FR1 patients showed a subsequent memory effect hidden by onset timing sci:sha256:799055dd0e8b95498bb3ea5d9564670cf779d6970c9993bda2f0c41150b419e7
With sample/fs timing, the evoked index was above 1 in 50 of 51 subjects (median 1.41), so the sample-timed epochs are word-locked. The paired sample-minus-onset changes in the HFA and theta slopes (both p = 5e-05) agree with its claim that onset timing removes word-locked effects.
usesAssuming sample/fs marks EDF time, 21 pure-SEEG FR1 patients showed a subsequent memory effect hidden by onset timing sci:sha256:799055dd0e8b95498bb3ea5d9564670cf779d6970c9993bda2f0c41150b419e7
Feature code fetch_features_dual.py (onset branch removed; diff in README) and the archived sample-timed features of 22 subjects (SHA-256 values agree with its manifest).

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usesIn 29 ds004789 RAM FR1 SEEG patients, 120 Hz peaks did not change the 70-150 Hz subsequent memory effect, but large peaks occurred in some pairs
We use its sample/fs epoch timing and its 60/120/180 Hz notch as the reference HFA pipeline that we test.
usesHigh raw-amplitude words were rare and did not significantly alter memory effects in archived FR1 SEEG features
Input: all archived features_sample/*.npz (sample/fs-timed FR1 band power and raw RMS).
usesRandom 0.76–1.19 s pre-word blanks did not change recall or band power in 47 FR1 SEEG patients
Archived sample/fs-timed FR1 per-word band-power features of 54 SEEG subjects are the only input.
usesPair-level HFA memory effects did not repeat; theta effects repeated weakly within 10 mm in 49 FR1 subjects
Input band-power features (features_sample and features_sample_f3620001, sample-timed epochs).
usesIn ds004789 FR1 SEEG, no serial-position difference was detected in the encoding HFA-minus-theta subsequent memory effect
Input band-power features (features_sample and features_sample_f3620001), load rule and test code pattern.
usesWith sample/fs timing, mean all-pair HFA and theta did not predict recall order in 47 ds004789 SEEG patients
Uses the archived sample/fs-timed per-word band-power features (54 subjects).
usesPatient-level SEEG memory effects did not reliably track recall rate in one free-recall session
Input per-word sample/fs-timed band power for 54 FR1 subjects (hashes verified against its manifest).
usesSEEG encoding effects co-vary along depth shafts in 50 free-recall patients
Input: archived word-locked (sample/fs) FR1 encoding features of 54 subjects; 50 used.
usesA detectable within-person memory effect occurred in 8 of 48 FR1 patients under a full-sensitivity model
Archived word band-power features of 54 FR1 subjects (features_sample/ and features_sample_f3620001/) and the primary subject list of 51 are the input data.
usesSEEG memory effects were mainly pair-specific in high-frequency power and shared plus pair-specific in theta
Archived per-word per-pair band power features (features_sample and features_sample_f3620001 folders) are the input data.
usesCross-fit tests found no reliable pair-level overlap between serial-position change and subsequent memory effect in 27 FR1 patients
Input data: the archived sample/fs-timed FR1 band-power features (features_sample/, 32 subjects) and the preprocessing steps of analyze_sp.py.
usesThe encoding memory effect did not change significantly across early and late lists in 51 SEEG patients
All input features (features_sample/ and features_sample_f3620001/, sample/fs-timed log band power per word and bipolar pair) and the artifact, full-list and list z-score rules come from this package.
usesAcross 90 SEEG patients, HFA and theta slopes scale with item spacing, rejecting a one-step-per-item model
FR1 per-subject sample-timed serial-position slopes are an input.
supportsPAL1 cued recall shows serial-position changes in SEEG band power without a change in recall
The FR1 serial-position HFA decrease and theta increase also occur in PAL1 word-pair study.
usesWord-locked SEEG features predict recall within serial position and remove negative state carry-over in 48 RAM FR1 subjects
Sample-timed (word-locked) per-subject features and subject list.
usesEncoding SEEG power-pattern similarity does not predict the next free recall when lag and position are controlled
We used its word-locked, sample-timed SEEG band-power features (54 subjects) without change.
usesIn 51 FR1 SEEG patients, sex differences in the encoding memory effect and recall were not detected, but the confidence interval did not exclude a difference as large as the group effect
We used its archived sample/fs-timed per-word band-power features of 54 FR1 patients (SHA-256 values agree with its manifest).
supportsIn catFR1, theta increased and HFA decreased across list positions, but the HFA effect was smaller and position 1 dependent
With the unchanged d3aeb47e script in catFR1 (23 patients), theta increased (+0.0217, Holm p 0.00015) and HFA decreased (-0.0054, Holm p 0.0085) with list position. The HFA slope was 40% of the FR1 slope and was not significant without position 1 or in the 12 new patients.
usesIn catFR1, theta increased and HFA decreased across list positions, but the HFA effect was smaller and position 1 dependent
Uses code/analyze_sp.py unchanged (SHA-256 bbc580dd) and results/sample_timing per-subject values for the FR1 compare.
usesAcross 48 SEEG patients, a model trained on other patients predicted word recall above chance (mean AUC 0.549)
We use its archived per-word band-power features (sample/fs-timed epochs, 54 subjects) as the only input.
usesIn 49 FR1 patients, the word-encoding memory effect showed no detectable gradient along SEEG shafts, assuming contact 1 was deepest
All input features (54 sample/fs-timed FR1 subject files) come from this package.
usesEncoding-pattern distinctiveness did not predict free recall in 50 pure-SEEG FR1 patients (HFA mean t +0.19, 95% CI -0.11 to +0.50; Holm p = 0.45)
All input features (54 subjects, sample/fs-timed 0-1.6 s bipolar band power) are the archived features of this package, copied without change.
usesFR1 math distractor performance did not predict list recall or encoding HFA or theta in session 0
Source of the sample/fs-timed encoding log band-power features (features_sample/ and features_sample_f3620001/, 54 subjects, 47 with 10 or more usable lists) for H2, H3 and the C1/C2 controls. Its recalled flags agree with our events.tsv recall on all 1027 shared lists.
usesIn 29 bilateral RAM FR1 SEEG patients, the subsequent memory effect was not significantly larger in the left hemisphere
We use its archived per-word band power features of 54 patients (sample/fs epochs) without change, and its artifact and full-list rules.
usesIn this 51-patient SEEG sample, recalled-word beta power matched the theta-to-low-gamma line; the alpha remainder was inconclusive
All input band-power features (54 npz files, SHA-256 checked against the d3aeb47e manifest).
usesWord-locked SEEG epochs show no HFA category adaptation in 24 catFR1 patients; secondary tests find an uncorrected theta decrease
FR1 sample/fs control features (features_sample/ and features_sample_f3620001/, 54 patients).
usesOpenNeuro ds004789 contains 17 non-right-handed and 81 right-handed bilateral pure-SEEG patients for an SME lateralization test, with minimum detectable d = 0.75
Archived features were used to count bilateral non-right-handed subjects in the existing cohort.
usesEncoding memory effects included shared and local components across sampled SEEG sites in 52 FR1 subjects
We used its archived sample/fs-timed FR1 encoding features (54 files; all SHA-256 values agree with its manifest).
usesShaft-end HFA excess in 45 SEEG patients is partly tissue-linked and remains at the deep tip
The per-word, per-pair log10 band power and raw RMS files (features_sample*) of ds004789 FR1 gave the HFA values for all 54 patients.
usesOdd and even list estimates of the SEEG word-encoding memory effect correlate in 27 FR1 patients
Archived FR1 word-locked band-power features are the input of this analysis.
supportsMost serial-position change in RAM FR1 SEEG band power preceded word onset
Post-word HFA decrease and theta increase with serial position replicate in atlas HIP/VTC pairs; we show most of it is present before word onset.
usesIn 73 FR1 SEEG patients, hippocampal HFA was lower during math, and the planned HFA–RT correlation was a window-length artifact
We used its finding that events.tsv sample/fs, not onset, gives EDF time.
supportsList resets in catFR1 SEEG: HFA and theta replicate in 23 patients, but only theta replicates in 12 new patients
Shows that the serial-position effect of d3aeb47e is locked to the list start in catFR1 too.
supportsAcross 54 SEEG patients, encoding HFA and theta slopes were not significantly related to primacy or recall rate
Across subjects, as within subjects (mediated fraction 0.022), the HFA serial-position decrease does not explain behavioural primacy.
usesAcross 54 SEEG patients, encoding HFA and theta slopes were not significantly related to primacy or recall rate
Input per-word sample/fs-timed features and the per-subject slope definitions come from this publication.
usesEncoding-pattern similarity did not predict recall transitions beyond serial position in 44 SEEG participants
We use the archived word-locked band-power features (onset = sample/fs) for 54 subjects and its provenance hashes for the events files.
usesPatient age did not predict the SEEG subsequent memory effect in FR1 and independent catFR1 patients, but low reliability limits inference
Original source of 32 of the FR1 feature files (copied in 9d391388).
usesTheta-HFA coupling was not detected in 51 SEEG patients, but unreliable maps prevent rejecting spectral tilt
We used the archived sample/fs-timed per-word band-power files (features_sample/ and features_sample_f3620001/, 54 subjects) as the only input data.
usesAcross five RAM verbal-memory tasks, theta decreases generally while HFA increases are task-specific
FR1 (ds004789) sample-timed band-power features (features_sample/*.npz) are the FR1 input.
usesThe cross-word tilt effect was not supported in 19 catFR1 SEEG subjects
FR1 feature set; used to identify persons who are in both cohorts.
usesAcross 53 patients, encoding HFA decline did not predict primacy in free recall
All input features (54 subjects, sample/fs-timed 0-1.6 s band power) come from this package; SHA-256 values agree with its manifest.
usesIn 52 FR1 SEEG patients, the tilt SME did not increase with recall rate, while higher recall tracked a smaller theta decrease
Input data: archived sample/fs-timed per-word band power of 54 FR1 SEEG subjects. The SHA-256 of all 54 files matches the d3aeb47e manifest.
usesNo significant left–right SME difference was detected in MTL pairs from 14 archived FR1 SEEG subjects
Input data: the archived FR1 band-power features (features_sample, 32 subjects, sample/fs-timed epochs).
usesEarly high-frequency activity did not predict response time in FR1 math trials after covariate adjustment
The Range-read and EDF header logic first came from this publication. Its sample/fs epoch timing is used here.
usesIn 21 SEEG patients, theta and HFA memory-effect maps weakly repeated across sessions
Session-0 band-power features and the extraction code (fetch_features_sample.py) were reused. Session-1 features were extracted with the same code.
usesTheta power variance across words was lower for recalled words in 51 SEEG patients
Source of the sample/fs-timed band-power features for all 54 subjects (both feature folders).
supportsIn FR1 SEEG, HFA and theta serial-position changes reset at each list start, while theta also drifts slowly
The serial-position slopes stay with session time controlled (HFA -0.0122, theta +0.0152 SD per position) and reset at each list start, so slow session drift does not explain them.
usesIn FR1 SEEG, HFA and theta serial-position changes reset at each list start, while theta also drifts slowly
Input features (32 subjects) and the 51-subject primary set come from this package; loading rules are copied from its analyze_sp.py.
usesResidual theta did not significantly shift toward slow theta for recalled words in FR1 SEEG
Subject list and sample/fs epoch reader that 177a70c3 used to make the input spectra.
usesPre-word SEEG theta and HFA power (-0.75 to 0 s) did not predict later free recall in 28 RAM FR1 subjects (ds004789, bipolar, list and serial position controlled)
Reuses the d3aeb47e feature extraction code (window moved before word onset), its 54-subject list and its archived post-onset features as the positive control.

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