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q-bio.NC · Neurons and Cognition

In 73 FR1 SEEG patients, hippocampal HFA was lower during math, and the planned HFA–RT correlation was a window-length artifact

We used 73 patients from OpenNeuro ds004789 (RAM FR1, session 0, bipolar SEEG, 492 hippocampal pairs). We compared hippocampal high-frequency activity (HFA, 70-150 Hz) in an 8-s window of the A+B+C math distractor with an 8-s window of the pre-list countdown. The plan was written before we read any neural data. HFA during math was lower by 0.0138 log10 units (about 3.1 % of power; 95 % CI 2.2-4.1 %). This was true in 58 of 73 patients (sign-flip p < 1e-4). Theta (3-8 Hz) did not change significantly. The planned per-problem test gave a strong positive correlation between HFA and response time (65 of 68 patients). But the same estimator, with the same window lengths, gave the same correlation on countdown data, where there is no problem (66 of 66 patients). With a fixed 1-s window, the correlation was near zero (mean Fisher z 0.024, CI -0.010 to 0.058). Thus the planned per-problem result is an artifact: mean log Welch power is biased down when a window has fewer segments. Limits: the countdown is passive digit viewing, not rest. The math period always follows encoding. The study did not separate aperiodic from narrowband power. The package has the code, the plan, per-subject provenance with SHA-256 values, results tables, and reproduction steps.

hippocampus · SEEG · high-frequency activity · math distractor · response time · Welch power · window-length bias · FR1

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References

4
  1. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    We used this census of OpenNeuro SEEG datasets to choose ds004789.

  2. usesFR1 math distractor performance did not predict list recall or encoding HFA or theta in session 0 sci:sha256:4224f68bf945a1232305111754308cd095195aacb09e169052ab0b50725ef629

    This publication studied FR1 math distractor behaviour. We add the hippocampal neural correlates of the same period.

  3. usesIn session 0, hippocampal 70–150 Hz power rose before correct recall, but not non-word vocalizations or intrusions sci:sha256:84a42bd21339f01488b7c08ea1383cf40e235d470e91c5464ceda16a2fd630ea

    We adapted the range-read EDF fetch code and used the hippocampal subject list from this publication.

  4. usesIn 51 pure-SEEG FR1 patients, sample-timed HFA decreased and theta increased with serial position sci:sha256:1da9d2dc0707f4d6cf26a2edf8d7e8f74cdb417581b20b70aafdf258db4aedc8

    We used its finding that events.tsv sample/fs, not onset, gives EDF time.

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