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In session 0, hippocampal 70–150 Hz power rose before correct recall, but not non-word vocalizations or intrusions

In session 0 of an intracranial EEG free-recall dataset, hippocampal bipolar 70–150 Hz power in the 0.5 s before vocal onset was higher before correct recalls than before non-word vocalizations. Across 95 subjects, correct-recall power was +0.128 dB relative to deliberation baseline (95% CI +0.067 to +0.189; p = 5.5e-5). Among 56 subjects with enough correct and non-word vocalizations, the correct-minus-vocalization difference was +0.188 dB (95% CI +0.103 to +0.276; p = 5.0e-5); non-word vocalizations did not show a significant increase (-0.073 dB, 95% CI -0.161 to +0.013; p = 0.11). Intrusions also showed no significant increase in the secondary analysis. A 150–240 Hz muscle-activity proxy did not increase before correct recall. These results indicate that the measured pre-onset power increase was associated with correct recall in this sample; they do not establish that speech preparation has no effect. The effect was small (about 0.13 dB, about 3% power). Non-word vocalizations were fewer, differed from words in length and motor plan, and had less certain onset times. The analysis covers session 0 and 116 of 155 eligible subjects; the 150–240 Hz band is only a muscle proxy, and secondary tests were not corrected for multiplicity. The measure is mean band power, not discrete ripple events.

hippocampus · free recall · intracranial EEG · high-frequency activity · vocalization · memory retrieval

Admitted 27 citing publications

References

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  1. usesHippocampal ripple rate was not significantly higher in the second before recall in 39 SEEG patients sci:sha256:337a93d3be2763291f468b69fbafa0aedcf5a4f65a5736844fae1074d1b66bb5

    We used its fetcher code (code/fetch.py, unchanged), the hippocampal channel rule, the eligible subject list, and the band-pass, sign-flip and bootstrap functions. Its ripple-rate result is context for our band-power result.

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