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q-bio.NC · Neurons and Cognition

Hippocampal pre-recall high-frequency power did not increase in 13 pyFR patients; the FR1 result was not replicated

In a preregistered replication using hippocampal stereoelectroencephalography (SEEG) from 13 patients in the pyFR delayed free-recall cohort (OpenNeuro ds004865 v2.0.1), 70–150 Hz power during the 0.5 s before correct vocal recalls did not differ from silent deliberation baseline (+0.026 dB, 95% CI −0.223 to +0.297, exact sign-flip p = 0.857; 6 of 13 subjects positive). The earlier FR1 increase (+0.128 dB, n = 95) was not replicated. Correct-minus-intrusion power was +0.118 dB (n = 11, p = 0.514), with the same sign and similar size reported in FR1 and catFR1, but was not significant here. After vocal onset, correct-recall power decreased by 0.247 dB (uncorrected p = 0.028). Sensitivity analyses gave the same primary conclusion. The study had low power: subject SD was 0.50 dB and the minimum detectable effect at 80% power was approximately 0.42 dB. Therefore, this null result does not show that the FR1-sized effect is absent. Timing uncertainty, event-label ambiguity, Talairach-based hippocampal labels, and small list counts in some sessions remain limitations.

hippocampus · free recall · high-frequency activity · stereoelectroencephalography · replication · pyFR · OpenNeuro

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References

5
  1. supportsIn 46 independent SEEG patients, hippocampal 70–150 Hz power did not increase before correct recall in catFR1 sci:sha256:f1a9acf48f9054e0e389af1a7337de85ab013f2c733138de6d69192b006112f9

    Like catFR1, pyFR shows no pre-recall HFA increase for correct recalls, and correct minus intrusion has the same positive sign (+0.12 dB, not significant).

  2. In session 0, hippocampal 70–150 Hz power rose before correct recall, but not non-word vocalizations or intrusions sci:sha256:84a42bd21339f01488b7c08ea1383cf40e235d470e91c5464ceda16a2fd630ea

    [Legacy relation: reproduces] Pre-registered replication of its pre-recall hippocampal HFA test and correct-minus-intrusion test in pyFR (ds004865); R1 did not replicate (+0.03 dB, p = 0.86, n = 13), but power is low (MDE approximately 0.42 dB).

  3. usesIn session 0, hippocampal 70–150 Hz power rose before correct recall, but not non-word vocalizations or intrusions sci:sha256:84a42bd21339f01488b7c08ea1383cf40e235d470e91c5464ceda16a2fd630ea

    code/fetch.py and code/analyze.py are adapted from this package; all analysis parameters are the same.

  4. usesIn 20 SEEG patients’ first eight free-recall lists, HFA decreased and theta increased across positions, while HFA predicted recall after position control sci:sha256:35b5dd24a197bdbc166dc2b58dea79b97a0047ffbf9de0940646cdd935c751ef

    The 20-subject pyFR SEEG list, the session rule and the timing-QC exclusion come from this package.

  5. usesdoi:10.18112/openneuro.ds004865.v2.0.1

    The analysis read recall-period EDF data and associated event, channel, and electrode files from OpenNeuro ds004865 version 2.0.1.

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