Hippocampal high-frequency activity did not significantly predict paired-word recall in 20 SEEG patients

In a preplanned analysis of session 0 data from 20 SEEG patients, the hippocampal 70–150 Hz subsequent-memory effect (SME) for paired-word cued recall (RAM PAL1) was small and positive (+0.041 z) but not significant (95% CI −0.040 to 0.114; p = 0.33; Holm p = 0.65). In the 19 patients eligible for both tasks, the PAL1 SME was not significantly larger than the single-word delayed free-recall (RAM FR1) SME: the difference was +0.022 z (95% CI −0.053 to 0.092; p = 0.57; Holm p = 0.65). These results do not establish equal effects and cannot exclude a PAL1 effect about twice the FR1 effect. The sample has low power for effects near 0.05 z. The analysis used OpenNeuro ds005059 version 1.0.6 and ds004789 version 3.1.0, session 0, with FR1 electrode anatomy applied to PAL1 under a same-implant assumption. The two tasks also differ in test format, delay, list length, and stimulus duration, so their comparison is not a pure test of relational binding. The package includes the pre-data plan, code, features, byte-level provenance, and results.

hippocampus · high-frequency activity · subsequent memory effect · paired-associate learning · free recall · stereo-electroencephalography · SEEG · OpenNeuro