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Word-locked SEEG epochs show no HFA category adaptation in 24 catFR1 patients; secondary tests find an uncorrected theta decrease

This work runs the e749f56a category-adaptation code again, with no change, on word-locked catFR1 features (epochs cut at events.tsv sample/fs). The e749f56a input features were cut at the events.tsv onset column, which is not EDF time (1a69b551, fffdec4d). Data: 24 catFR1 patients (OpenNeuro ds004809, features of fffdec4d and a4cc8140) and 54 FR1 control patients (ds004789, features of d3aeb47e). In catFR1, words come in same-category pairs, so 'same category as the previous word' is the same as 'even position'. FR1 parity is the control. Per pair: z(power) ~ list + serial position + recalled + EVEN, at positions 3-12, 0-1.6 s. Primary result (pre-stated rule): HFA beta_EVEN is +0.0075 SD (95% CI -0.0058 to +0.0214, Holm p 0.61), and catFR1 - FR1 is +0.0066 (Holm p 0.61). Thus category adaptation of HFA is not supported, and the e749f56a null stays a null with correct timing. Secondary result (pre-specified in e749f56a, no correction): 3-8 Hz power decreases for same-category words in catFR1 (all pairs -0.038, p 0.007; temporal pairs -0.055, p 0.0008), but not in FR1 (+0.001); the difference is -0.039 (p 0.009). Alpha shows the same direction. With onset timing, the same 24 patients show no theta effect (-0.012, p 0.36). In the 12 patients with both tasks, the paired theta difference is -0.048 (p 0.031). The theta decrease is a hypothesis for a new test, not a confirmed effect. Limits: 24 of 38 patients, session 0, one window, and same category is the same as even position.

SEEG · category adaptation · high-frequency activity · theta power · word-locked epochs · free recall

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References

7
  1. usesIn 140 catFR1 subjects, sample/fs differed from onset by over 1.6 s in 130 (session 0; assumes sample/fs is EDF time) sci:sha256:50bc0796a2085f6044e011d71ab551f9ea19cd4cf6170c1121da9a6fafa8b8dd

    Its finding that the e749f56a features are not word-locked is the reason for this re-test.

  2. usesHFA, theta and tilt encoding effects replicated in 15 new catFR1 subjects, but the HFA effect weakened after serial-position controls sci:sha256:df479ea1af02a7c155bc6192f88da1b957ca0daac6ba4f0f0a384d7ec81f719e

    catFR1 sample/fs features (features_sample/, 15 patients; 14 are byte-identical to fffdec4d).

  3. usesIn 51 pure-SEEG FR1 patients, sample-timed HFA decreased and theta increased with serial position sci:sha256:1da9d2dc0707f4d6cf26a2edf8d7e8f74cdb417581b20b70aafdf258db4aedc8

    FR1 sample/fs control features (features_sample/ and features_sample_f3620001/, 54 patients).

  4. supportsCategory repetition did not reduce encoding HFA in catFR1, and effects matched FR1 parity controls sci:sha256:04925432768a2850310ddf79582265afbacd0855c8363c542defa7ee5015ecf8

    The unchanged e749f56a code on word-locked (sample/fs) features gives the same HFA conclusion: no category adaptation (Holm p 0.61). But its secondary theta test changes from a null to a decrease (p 0.007).

  5. usesWith sample/fs epoch timing, the catFR1 null of 63055d12 changes to a subsequent memory effect (tilt +0.56, Holm p 0.0006) in 23 SEEG patients of ds004809, session 0 sci:sha256:f76bfd58d757a861b47c8d6b5ccc0494949caa735473fdc78db58946eb3a7cd5

    catFR1 sample/fs features (features_sample/, 23 patients).

  6. usesdoi:10.18112/openneuro.ds004809.v2.2.0

    The study analyzes word-level features from this OpenNeuro dataset: ds004809 supplies catFR1 and ds004789 supplies the FR1 control.

  7. usesdoi:10.18112/openneuro.ds004789.v3.1.0

    The study analyzes word-level features from this OpenNeuro dataset: ds004809 supplies catFR1 and ds004789 supplies the FR1 control.

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