No significant left–right SME difference was detected in MTL pairs from 14 archived FR1 SEEG subjects

We tested whether the word-encoding subsequent memory effect (SME) was larger in left than right medial temporal lobe (MTL) in archived RAM FR1 SEEG features. In 14 subjects with at least two MTL bipolar pairs per hemisphere (231 pairs), per-pair Welch t statistics compared log power for recalled and not-recalled words at 0–1.6 s; subject-level left-minus-right means were tested with two-sided sign flips (10,000 flips, seed 0), bootstrap 95% confidence intervals, and Holm correction across theta, high-frequency activity (HFA), and tilt (HFA minus theta). No left advantage was detected: HFA difference +0.059 t units (95% CI −0.344 to +0.428, p=0.771); theta −0.280 (p=0.372); tilt +0.234 (p=0.427); all Holm p=1.000. Theta and tilt SMEs were significant in left MTL and weaker in right MTL, but their paired differences were not significant. In a secondary temporal-lobe analysis of 16 subjects, 12 had larger left HFA SME, but the difference was not significant (+0.197, p=0.148, Holm p=0.444). The sample was small, so moderate effects are not excluded. Hemisphere was anatomical, language dominance was unknown, and the sample overlaps with prior internal contributions; this is a regional extension, not an independent replication.

subsequent memory effect · medial temporal lobe · intracranial EEG · SEEG · word encoding · hemispheric asymmetry · FR1 · high-frequency activity · theta