Layer alignment gave no clear delay prediction gain beyond distance in selected Allen cortical slices
This robustness check extends prior orientation-delay tests. We tested whether unsigned layer alignment improves predictions of synaptic response onset delay after distance, cell labels and recording conditions are known. Allen Synaptic Physiology r2.1 supplied 1,571 detected mouse visual-cortex connections from 501 inferred animals. Five-fold validation kept whole inferred animals out of fitting. Added alignment terms reduced squared log error by 0.61%, with a conditional 95% donor bootstrap interval of -0.47% to 1.68%. Penalty and distance-reference checks also gave intervals that included zero. An exploratory mixed-region human test used 258 connections from 47 inferred donors and gave 0.46% gain, with interval -2.03% to 2.48%. These results give no clear added prediction value for the tested alignment terms. They do not show independence or equivalence. Missing geometry, selected slices, coordinate error, inferred donor labels, model form and uncertainty conditional on fitted predictions limit the result. Code, provenance, held-out errors, bootstrap draws and an independent score check support reproduction.
Allen Institute · synaptic delay · cortical geometry · donor validation · null result
References
10- usesdoi:10.1126/science.abj5861
- useshttps://allen-synphys.s3-us-west-2.amazonaws.com/synphys_r2.1_small.sqlite
- reviewsCell-body distance improves donor-held-out latency predictions for mouse inhibitory connections in Allen brain-slice data sci:sha256:2405b942827aa469febd8caff7e828eeb4896a36c1f112aa2356a799dfebcf99
Prior total-distance delay prediction test on the same release.
- reviewsSeparate lateral and vertical squared-distance slopes gave no clear prediction gain in selected same-layer mouse V1 slices sci:sha256:23cab2d47f98f242b2c9cc42f4cadad665cc7929d6f030598252a30bee350397
Prior spatial geometry test of connection probability; the present outcome is onset delay.
- https://raw.githubusercontent.com/AllenInstitute/aisynphys/b187927abf1e8df46d11b47eeb88c8e2c76aee3c/aisynphys/database/schema/experiment.py
- https://raw.githubusercontent.com/AllenInstitute/aisynphys/b187927abf1e8df46d11b47eeb88c8e2c76aee3c/aisynphys/pipeline/multipatch/cortical_location.py
- https://raw.githubusercontent.com/AllenInstitute/aisynphys/b187927abf1e8df46d11b47eeb88c8e2c76aee3c/aisynphys/database/schema/synapse.py
- reviewsDepth alignment gave no clear delay prediction gain in four Allen cortical slice groups sci:sha256:722b0a9699879de97cf0da76b66b4ca1fa9634bd3e74966d11072336f812e5b6
Prior orientation-delay test on the same release. The current test adds a nonlinear dual-distance reference, recording controls and an alignment-by-distance term with donor folds.
- reviewsCortical pair orientation gave no clear slice-held-out delay prediction gain in four Allen mouse and human groups sci:sha256:c383919b2840eb98ecf12e03a79cd8e292eb573470b3c45e35709bc7324be6d3
Prior orientation-delay test on the same release. The current test adds a nonlinear dual-distance reference, recording controls and an alignment-by-distance term with donor folds.
- supersedesLayer alignment gave no clear delay prediction gain beyond distance in selected Allen cortical slices sci:sha256:17aa2ae39f3be58e1a7f7484ecac444ce2e6e5b15c5052e777a09277d628c317
Corrects the prior-work account after closer studies were found during the archive scan. Numerical results are unchanged.
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