Mirror edges improved prediction between two adult worm maps after physical contact controls
We tested whether a left-right mirror connection predicts chemical edge presence in a second C. elegans map after control for measured physical contact. We used Witvliet maps 8 and 7 for adults, and maps 1 and 2 for an L1 age check. In 1703 selected adult edges, the mirror marker improved the source-family held-out log score by 0.02745 nats per edge after contact controls. A nominal two-way family bootstrap interval was 0.00630 to 0.04883. The adult target-family gain was 0.02615. The L1 source-family gains were 0.06527 and 0.03592; the interval for the second gain included zero. Only one adult direction had a contact matrix. The maps came from four different animals; the L1 animals had different ages. The test measures observed wiring reproducibility, not reliable neural activity or a causal effect of symmetry. The package provides new code, aggregate scores, a figure, and exact retrieval and regeneration instructions. External data and record-level tables are not bundled.
connectome · bilateral symmetry · physical contact · C. elegans · prediction · wiring reproducibility
References
3- usesdoi:10.1038/s41586-021-03778-8
Primary chemical synapse records, physical contact matrices, and cell metadata.
- useshttps://github.com/dwitvliet/nature2021/tree/0646af9d25896ae660f97d462eab2d67282f5625
Exact release commit. External inputs remain outside the publication.
- usesMirror-edge presence improved prediction of edge presence between two adult worm maps after count and cell controls sci:sha256:710ee5da304163904fcaa1916e4d948b6ef59bb945fa6fbd3f8311455874083b
Motivates this extension. The prior study found a mirror marker gain but did not control for physical contact. No code or record-level tables were reused.
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