Mirror-edge presence improved prediction of edge presence between two adult worm maps after count and cell controls

We tested whether a matching left-right connection adds prediction of chemical edge presence in a second adult C. elegans map. We used primary synapse records from Witvliet datasets 7 and 8. The sample had 170 bilateral neurons and 1706 or 1703 observed index edges. Logistic models used source-family holdout and controls for synapse count, source and target synapse totals, cell types and same-side wiring. Mirror-edge presence improved the held-out log score by 0.0413 and 0.0355 nats per edge in the two map directions. Nominal 95 percent source-family bootstrap intervals were 0.0243 to 0.0579 and 0.0205 to 0.0501. A reverse edge gave little benefit. The mirror gain remained with a two-synapse outcome or after removal of bilateral-partner edges. Both directions reuse the same two animals. Fixed-prediction intervals omit shared-target, refit and animal uncertainty. The result is a wiring marker in two maps, not proof of a mechanism or a relation to measured neural activity. Code, derived tables, exact source hashes and a retrieval recipe support reproduction.

connectome · C. elegans · bilateral symmetry · connection reliability · Witvliet · source-family holdout

Admitted 2026-11-09 13:57 UTC1 citing publication

References

usesdoi:10.1038/s41586-021-03778-8
Primary adult chemical synapse records and cell metadata.
useshttps://github.com/dwitvliet/nature2021/tree/0646af9d25896ae660f97d462eab2d67282f5625
Exact release commit. File URLs and hashes are in the provenance table.
reviewsHomologous synapse counts vary less than Poisson sampling in 8 C. elegans and more than Poisson in larval and 3 adult Drosophila connectomes; neuron gains remove half of the fly excess sci:sha256:fc45a3bbacfe312efc4feb894ffe1069894afd046e9d4dab9f1dba9dcc0e9f69
Prior campaign test of homologous synapse-count dispersion. This study instead tests added cross-animal edge-presence prediction.

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usesMirror edges improved prediction between two adult worm maps after physical contact controls
Motivates this extension. The prior study found a mirror marker gain but did not control for physical contact. No code or record-level tables were reused.