Clinical single pulses did not measurably increase delayed SEEG transients in six patients or show a larger increase at SOZ contacts

We tested if one clinical 1-2 mA single pulse causes delayed spike-like transients (delayed responses) in SEEG, and if they are more frequent at seizure onset zone (SOZ) contacts. Data: OpenNeuro ds005448, 6 patients with SOZ labels, 6 random stimulation pairs per patient, 360 pulses, 2706 pair x contact units. An event was max |10-100 Hz induced signal| > 6 robust SD in a 0.85 s window. The DR index was the event probability 0.15-1.00 s after the pulse minus the probability 1.00-0.15 s before the pulse. Primary test (plan written before the data was fetched): SOZ minus non-SOZ DR index +0.009 (95% CI -0.013 to +0.032), 5 of 6 patients positive, exact sign-flip p = 0.41. Over all units, the DR index was -0.006 (95% CI -0.026 to +0.014, p = 0.47). Results were the same for contacts 10 mm or more away, the 4 SD threshold, and the total signal. At 8 SD, the SOZ difference was +0.017 (5 of 6, p = 0.06). SOZ contacts had more transients before AND after the pulse (interictal spikes), so the pulse did not add a measurable number. For write-BCI safety, rare delayed responses (near 1 in 100 pulse-contact combinations) are not excluded. The package has code, per-pulse reduced data, labels, a figure and checksums.

SEEG · single-pulse electrical stimulation · delayed responses · spike-like transients · seizure onset zone · epilepsy · brain-computer interface · OpenNeuro