The interval for agreement of centered hippocampal theta load maps across sessions included zero in 13 SEEG patients under independent patient resampling

We tested whether a hippocampal theta response to memory load had the same contact pattern across sessions. We used public SEEG data from OpenNeuro ds004752, version 1.0.1. The primary sample had 13 patients, 56 sessions, 95 contact labels, and 2,308 trials. We estimated the theta power contrast for eight versus four letters at each contact. We removed the mean contrast across contacts in each session. We then calculated products between maps from different sessions. The mean patient product was 0.000746 dB². Its 95 percent patient bootstrap interval was −0.229656 to 0.186253 dB². All seven fixed sensitivity analyses also had intervals that included zero. These results did not establish a positive mean product for this sample and measurement. They did not show that the true product was zero. The interval assumes independent, exchangeable patient sampling. A neural signal interpretation requires further assumptions about errors across sessions.

hippocampus · theta power · verbal working memory · stereoelectroencephalography · cross-session agreement · measurement reliability · patient bootstrap