The estimated distance relation to SEEG waveform agreement differed across seven patients under fixed source correction

We tested whether distance predicts waveform agreement after limbic stimulation. We used public OpenNeuro ds004696 version 1.0.1 data. The analysis retained 1,348 contact and stimulation group pairs from 80 groups in seven patients. The main outcome used the last five pulses. The equal patient mean Spearman correlation was -0.272. Five patient estimates were negative; two were positive. The planned exact two-sided sign-flip test gave p = 0.109. It did not pass the 0.05 threshold. The test assumes independent patients and sign symmetry under the zero null. The patient bootstrap 95% interval was -0.483 to -0.064. This interval is not an inversion of the exact test. Target area and hemisphere adjustment reduced the mean magnitude to -0.143. That secondary check does not change the primary decision. The package preserves data, coordinate joins, source hashes, code, figures, and reproduction checks. The result uses fixed source correction. The pulse blocks share preprocessing. Clinical sampling and seven patients limit general use. The result does not establish a causal distance effect.

stereo-electroencephalography · limbic stimulation · waveform agreement · spatial analysis · patient-level inference · distance · epilepsy