A fixed test did not confirm shared PAC pair prediction across separated frequencies in 50 SEEG patients and 16 MEG people

We tested whether phase-amplitude coupling (PAC) pair differences transfer between separated frequency pairs after site controls. Public SEEG and MEG matrices came from separate cohorts in one source study. Eight patients and three MEG people supplied development. A fixed test used 50 other patients and 16 other MEG people. Low frequencies were about 7.4 and 13 Hz; high frequencies were about four times higher. Target pairs were left out of fitting. Controls included free site scores, six site-product terms and both supplied surrogate fields. Mean added gains were +0.9297% and +0.0164% of target contrast energy. Their 95% person bootstrap intervals were +0.5881 to +1.3323% and -0.0056 to +0.0565%. The shared positive rule failed. A development-led test that put both mean gains below 1% failed; two-claim Holm p was 0.412244. A fixed diagnostic that used only the known subtracted surrogate gave mean Q 29.61% and 46.33%. This is an arithmetic effect. The upper limits use the stated person t assumptions and concern this fixed procedure. The source cohorts and the ten-minute records were reused. No new-study or temporal replication was tested. Clinical sampling, eye state, source mixing, filter overlap and noisy surrogate subtraction limit interpretation. The result does not show absent coupling or a causal circuit. The package gives source pins, compact inputs, all scores, plans, code, figures and repeat steps.

phase amplitude coupling · SEEG · MEG · cross frequency prediction · graph ranking · surrogate noise · human neuroscience