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An inverse-sinh transform tests positive rank-one compatibility; fixed link prediction failed in human SEEG, MEG and EEG

We tested whether alpha-beta phase synchrony (CFS) helps predict phase-amplitude coupling (PAC) role differences after additive site scores are controlled. Public matrices supplied separate SEEG, MEG and EEG cohorts. Twelve SEEG patients supplied development. Fixed tests used 47 other patients, 19 MEG adults and 29 EEG adults from a separate study. Mean added gains were 1.383%, 0.378% and 0.677% of adjusted PAC contrast energy. Positive gains occurred in 27/47, 10/19 and 12/29 people. The shared mean-and-majority rule failed, p=0.867535. All negative results remain. An explicit common-phase model gave raw link cycles while every local coupling value was 0.1. Independent observation noise was sufficient; there were no links between observed sites. From this model, we derived an inverse-sinh compatibility test for positive rank-one completion from local values and reciprocal differences. A bounded-error version uses linear feasibility. One hundred random graph checks and twenty bounded-error checks passed. The test concerns compatibility, not the actual full matrix rank or a neural cause. A later exploratory human prediction reader gave no shared gain and had negative mean gain in EEG. Source noise limits were unavailable, so sample cycle residuals were not used to reject a human model family. Clinical sampling, source mixing, eye state, frequency averaging and reused cohorts limit scope. The package gives code, permitted inputs, source versions and terms, all results, plans, four figures and repeat instructions. No positive cross-modal neural or causal claim is made.

cross-frequency coupling · SEEG · MEG · EEG · phase-amplitude coupling · rank-one compatibility · graph cycles · negative result · reproducible research

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References

11
  1. usesSite scores reduced alpha-beta role error at omitted links in SEEG and MEG; EEG gains did not pass a fixed reference test sci:sha256:6746c5c4720d80d7cde641006b5bb6a91b68d6ac49755a83b07537779a1ea301

    We reuse its permitted compact native inputs, EEG coupling matrices, source readers and provenance. We test a new link-level predictor and a nonlinear compatibility diagnostic.

  2. usesA fixed test did not confirm shared PAC pair prediction across separated frequencies in 50 SEEG patients and 16 MEG people sci:sha256:6920a0c01c80592f72557bbdf3f4270f0fed5db52fd1ced807fef3807e68a9fa

    Its reference-subtraction warning motivated the added descriptive reference-covariate control. Our primary endpoint and inverse-sinh method differ.

  3. usesdoi:10.1371/journal.pbio.3000685

    Original SEEG and MEG acquisitions and coupling estimators.

  4. usesdoi:10.5061/dryad.0k86k80

    Public native coupling matrices, Dryad version 5, through pinned NEMAR nm000389 v1.0.2.

  5. usesdoi:10.82901/nemar.nm000389.v1.0.2

    Pinned derivative release v1.0.2.

  6. usesdoi:10.82901/nemar.on004504.v1.0.0

    Version-specific mirror of the separate OpenNeuro ds004504 v1.0.9 EEG study, healthy controls only. The source-reported OpenNeuro version DOI returned 404; its version URL and this mirror were available.

  7. usesdoi:10.3390/data8060095

    Original EEG data descriptor.

  8. doi:10.1109/ACCESS.2023.3294618

    Source-requested EEG attribution.

  9. doi:10.1007/s11571-026-10464-w

    Source-requested EEG benchmark attribution. No diagnosis is tested.

  10. usesdoi:10.1007/s10107-010-0419-x

    Established graph site projection and cycle decomposition.

  11. doi:10.1016/j.conb.2014.08.002

    Established interpretation limits for cross-frequency coupling.

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