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q-bio.NC · Neurons and Cognition

Electrical links had positive adjusted calcium correlation terms before and after heat in 19 C. elegans worms, with no clear change relative to 21 controls

Does an electrical link retain information about shared neural activity after a behavior change? We used all 40 labeled recordings from a fixed version of the Atanas and Kim dataset and the complete 302-neuron Cook reference graph. We compared 240-second windows before and after a one-second heat pulse in 19 worms, with time change in 21 baseline worms as the comparison. The model removed measured behavior separately in each window and controlled neuron identity, chemical wiring, class, ganglion and soma distance. The mean electrical term was 0.0392 Fisher z units before heat and 0.0412 after heat. Every heated worm had positive terms in both periods. The heat-minus-baseline change was -0.0004, with a 95 percent animal bootstrap interval from -0.0107 to 0.0106. Feeding fell from 0.729 to 0.016 Hz in heated animals. Specified checks of window length, behavior controls, labels and two native adult maps also gave no clear average change. The result extends the electrical association to activity after a large measured behavior change. It does not prove constant coupling or an electrical mechanism. Anatomy came from other animals, condition cohorts differed in date, and the test excluded the acute heat response. The package preserves code, 142,152 animal-pair entries, source checksums, results, figures and repeat instructions.

connectome · Caenorhabditis elegans · electrical synapse · calcium imaging · behavioral state · heat input · structure and function · reproducible analysis

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References

6
  1. usesElectrical links in three C. elegans maps had positive calcium correlation terms after behavior and wiring controls in 21 worms sci:sha256:b09f3c1a6080d1de06e526c73820f221c72e197b652af1ae224a632b69bafc1e

    We adapt its graph and pair utilities and extend its baseline analysis to the 19 labeled heat recordings that it excluded.

  2. usesdoi:10.1016/j.cell.2023.07.035

    We use its neural recordings, behavior measures, neuron identities and heat-input experiment.

  3. usesdoi:10.5281/zenodo.19388374

    This fixed version supplies the processed HDF5 archive and neuron identity export.

  4. usesdoi:10.1038/s41586-019-1352-7

    The corrected July 2020 workbook supplies the complete primary neuronal reference graph.

  5. usesdoi:10.1038/s41586-021-03778-8

    We use native adult maps 7 and 8 as checks of the anatomical reference.

  6. doi:10.1038/s41467-020-17218-0

    Its circuit experiments show that electrical connections can affect neural correlations and behavior. This motivates a test of the association across epochs.

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