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A fixed ECG correction increased 1–40 Hz SEEG time asymmetry in six of nine adult rest records at a 31.25 ms rank lag

This study tested a fixed ECG correction in nine adult rest SEEG records from OpenNeuro ds003688 version 1.0.7. The study used 578 good SEEG contacts and a 1–40 Hz filter. A linear model used early data for fitting. It corrected a separate later segment. Three-value rank patterns at a 31.25 ms lag gave a Jensen-Shannon time asymmetry score. The score increased in six records and decreased in three. The equal-adult mean increased from 0.000893709 to 0.000927514. The primary comparison used 99 shifted ECG models per adult. Mean shifted-minus-recorded residual score was -0.000034584 nats. The 95% participant bootstrap interval was -0.000095199 to 0.000018337. The two-sided sign-flip p value was 0.3086. This model did not show a reliable group decrease. Fixed checks showed that the direction could change with rank lag and reference. The 62.5 ms result was nominal; its p value was 0.1406 after adjustment for six sensitivity comparisons. A separate proof showed that exact removal of a known independent component can increase process time asymmetry. A post-result simulation illustrated that limit. It does not model the heart. The package preserves all nine short inputs, code, source versions, hashes, controls, model coefficients, results, and run instructions. Fresh source ranges rebuilt all nine archives with exact hashes. An offline repeat matched all scientific outputs. The study cannot separate cardiac artifact, neural heart responses, and shared noise. Its scope is nine selected clinical records and one correction procedure.

SEEG · ECG correction · ordinal time asymmetry · Jensen-Shannon divergence · physiological artifact

Admitted 2 citing publications

References

7
  1. usesMean ordinal time asymmetry exceeded IAAFT controls in 60 s SEEG windows from two contacts per patient for 36 HUP patients under the supplied reference sci:sha256:c0aa869fe063157a8ea057e937a01f8a6313305df4e720fe4a6bcd0daec9b559

    This study used the earlier ordinal SEEG time asymmetry finding to form the ECG correction question. No data or result from that cohort enters the new calculations.

  2. usesBipolar reference changed linear ECG prediction skill in both directions compared with common average reference in nine adult rest SEEG records sci:sha256:0ab9025de2c32e339ac12889a218c711c42b734b2f0263ba9eb03b05afa008c3

    This study reused all nine short SEEG and ECG input archives, metadata selection, source provenance, retrieval code, and fixed model settings. It tested a new ordinal time asymmetry endpoint in the same records. It is not a new cohort replication.

  3. usesdoi:10.18112/openneuro.ds003688.v1.0.7

    The study analyzed nine short SEEG and ECG archives derived from OpenNeuro ds003688 version 1.0.7.

  4. doi:10.1038/s41597-022-01173-0
  5. usesdoi:10.1063/1.5055855

    The study follows this paper’s ordinal distribution and Jensen-Shannon approach.

  6. doi:10.1016/j.neuroimage.2013.05.042
  7. doi:10.1093/cvr%2Fcvaf099

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