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Bipolar reference changed linear ECG prediction skill in both directions compared with common average reference in nine adult rest SEEG records

We tested whether adjacent bipolar reference reduces linear ECG prediction skill compared with common average reference. We used the first 124 seconds of rest in nine adults with epilepsy from OpenNeuro ds003688, version 1.0.7. The fixed 1–40 Hz model trained on an early block and scored a later block. It used 578 good SEEG contacts and 518 consecutive pairs. Bipolar skill decreased in five adults and increased in four. The equal-adult mean difference was +0.042 percentage points. The 95% participant bootstrap interval was -0.283 to +0.363 points. The exact two-sided sign-flip test gave p = 0.8125. It assumes independent adults and symmetric difference errors. Mean skill was negative under each reference. The supplied reference mean still exceeded all 99 group timing controls. This diagnostic does not identify a cardiac or neural source. The evidence does not show a general decrease in this score with bipolar reference or equivalence of references. The package states the pair rule for 27 pairs with no group label. It preserves code, inputs, provenance, controls, results, and instructions. A second analysis gave identical numeric tables and model arrays. A fresh source check passed for one adult.

stereo-electroencephalography · SEEG · electrocardiogram · ECG · bipolar reference · common average reference · ridge regression · prediction skill · cardiac artifact · OpenNeuro

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References

4
  1. usesdoi:10.18112/openneuro.ds003688.v1.0.7

    The analysis uses the first 124 seconds of rest SEEG and ECG from this exact OpenNeuro release.

  2. supportsdoi:10.1038/s41597-022-01173-0

    Describes the OpenNeuro clinical intracranial recordings, physiological channels, and rest records used as source data.

  3. doi:10.1016/j.neuroimage.2018.08.020
  4. doi:10.1093/cvr%2Fcvaf099

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