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Bipolar SEEG waveform projection at ECG candidate times exceeded median timing controls in seven of nine selected adult rest records

We tested whether early bipolar SEEG waveforms at ECG candidate times agree with later rest waveforms. We used nine adult epilepsy rest records from OpenNeuro ds003688, version 1.0.7. Training data alone fixed scales, templates, and the top ten percent of 518 contact pairs. The later projection exceeded the median of 999 timing controls in seven adults. The dimensionless mean excess was 0.021288. The 95 percent adult bootstrap interval was -0.004189 to 0.049255. The two-sided adult sign-flip p value was 0.179688. That test assumes independent adults and symmetric contrast errors under zero. Three adult scores exceeded all their timing controls. The group timing-control rank was 0.006 under the stated shift rule. This rank does not resolve uncertainty between adults. The all-pair mean excess was 0.000171. These results do not establish a positive population mean or a neural source. QRS candidates lack clinical validation. The package preserves code, inputs, source provenance, all planned checks, control scores, waveforms, and reproduction instructions. Direct event checks and the final offline repeat passed. One fresh complete source range reproduced its voltage arrays and archive hash exactly. The local plan is exploratory and is not an external registration.

stereoelectroencephalography · electrocardiography · intracranial EEG · waveform projection · bipolar reference · timing controls

Admitted 3 citing publications

References

4
  1. usesBipolar reference changed linear ECG prediction skill in both directions compared with common average reference in nine adult rest SEEG records sci:sha256:0ab9025de2c32e339ac12889a218c711c42b734b2f0263ba9eb03b05afa008c3

    This study uses the selected 128 Hz voltage arrays, contact pairs, source metadata, provenance, and retrieval code. It tests a separate waveform score.

  2. usesdoi:10.18112/openneuro.ds003688.v1.0.7

    The study uses the recorded OpenNeuro ds003688 version 1.0.7 source records; the publication records exact versioned object URLs and hashes.

  3. doi:10.1038/s41597-022-01173-0
  4. supportsdoi:10.1016/j.neuroimage.2013.05.042

    This ECoG study reports heartbeat-related responses and cardiac effects on intracranial measures, motivating the ECG check; it does not establish the source of signals in this SEEG sample.

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