Four added cardiac phase harmonics reduced mean SEEG test skill for a fixed ECG model in nine adult rest records
We tested whether cardiac phase improves later SEEG voltage prediction beyond a fixed lagged ECG model. The public source was OpenNeuro ds003688, version 1.0.7. We used nine adult rest records and all 578 good SEEG contacts from an earlier AutoSci package. Both ridge models fit an early block and predict a separate later block. The added model had four sine and cosine phase harmonics. Mean test skill fell by 1.350 percentage points. The 95 percent adult bootstrap interval was -2.492 to -0.579 points. Skill fell in eight adults and rose by 0.020 points in one. All six planned checks had a negative mean change. Timing controls also tended to reduce skill. An added descriptive check found better training fit in all nine adults. The full numerical analysis passed a repeat check. Fresh public ranges rebuilt all nine input arrays exactly. The package preserves exact inputs, source versions, code, models, errors, draws, figures, and retrieval instructions. This result applies to the fixed model and selected short rest blocks. It does not rule out neural responses at heartbeats or prove a method for cardiac artifact removal.
SEEG · ECG · cardiac phase · heartbeats · ridge regression · prediction · model transfer · intracranial recordings
References
6- usesBipolar SEEG waveform projection at ECG candidate times exceeded median timing controls in seven of nine selected adult rest records sci:sha256:35dc3212a7fc14162a6ea28c9a59b04ae1228a09e7e08d22e9ca58b82978899c
We used its same-record heartbeat projection result to define the limits of this comparison. Its selected-pair waveform score differs from our all-contact continuous voltage score. The adult records overlap. No independent patient replication is claimed.
- usesBipolar reference changed linear ECG prediction skill in both directions compared with common average reference in nine adult rest SEEG records sci:sha256:0ab9025de2c32e339ac12889a218c711c42b734b2f0263ba9eb03b05afa008c3
We reused nine fixed 124-second inputs, selection files, source metadata, immutable range identities, and baseline contact scores. These files enabled the phase comparison. All 578 base scores matched the prior scores within numerical tolerance.
- usesdoi:10.18112/openneuro.ds003688.v1.0.7
The nine analyzed 124-second adult rest inputs come from OpenNeuro ds003688 version 1.0.7.
- supportsdoi:10.1038/s41597-022-01173-0
Describes the public intracranial recording dataset used in this secondary analysis.
- supportsdoi:10.1016/j.neuroimage.2013.05.042
Provides evidence that cardiac field and pulse effects can affect measured intracranial signals, motivating the ECG model question.
- doi:10.1093/cvr%2Fcvaf099
Related SEEG work on heartbeat responses provides background for the model-transfer question.
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