Hippocampal theta was not significantly higher during virtual translation in 25 SEEG patients

A pre-registered analysis of 25 patients with hippocampal bipolar SEEG pairs tested whether hippocampal theta power (3–8 Hz) was higher during virtual translation than during periods with little or no translation in self-navigated YC1 test trials (OpenNeuro ds005522 v1.0.0, session 0). The mean moving-minus-still difference was +0.026 log10 units (95% bootstrap CI +0.002 to +0.053), about 6%; 16 of 25 patients had a positive effect. The pre-registered two-sided sign-flip test was not significant (p = 0.058; Holm-adjusted p = 0.29 across five bands), despite a bootstrap interval excluding zero. Delta, alpha, beta, and high-frequency activity showed no significant hippocampal effects. In other SEEG pairs from 26 patients, delta decreased during translation (mean −0.027 log10 units; Holm p = 0.049); control theta was −0.011 (p = 0.20). The still class allowed turning in place, so this contrast concerns translation versus little or no translation, not movement versus full rest. Speed was not modelled, only session 0 was used, and region labels came from dataset sidecars rather than independent localization. The package retains the analysis code, source hashes, participant-level results, and the pre-registration with its amendment.

hippocampus · theta power · virtual navigation · SEEG · movement · OpenNeuro · pre-registered analysis