Wake and N3 coupling maps had positive agreement in SEEG and fMRI under mean and distance controls; SEEG agreement was uncertain after site control

We tested whether spatial coupling patterns persist from wakefulness to N3 in separate human SEEG and fMRI studies. The strict primary removed mean local signal, distance and additive endpoint site effects. It did not confirm shared retention. Corrected map cosine was 0.04650 in 41 SEEG patients (95% person interval -0.00207 to +0.09904; p=0.07985) and 0.35736 in 16 fMRI participants (+0.29929 to +0.41615; p=0.00008). A planned secondary test kept endpoint site effects and removed mean signal and distance. It found positive agreement in both: SEEG 0.09176 (+0.03796 to +0.14893) and fMRI 0.34750 (+0.28875 to +0.40687). Its joint Holm p was 0.02955 across all 15 signed temporal and spatial contrasts that can test a shared prediction in this run. This is a limited secondary cross-modal result, not a successful strict primary. The metric was observed wake-N3 residual-map cosine minus its independent-phase mean. It retained local window spectra and repeated mean signal regression in every draw. The data were MNI normal depth recordings and Tagliazucchi/Lehue BOLD. Signals, physical frequencies, sampling, and cohorts differ. Short records, clinical coverage, missing motion covariates, and prior BOLD processing limit the scope. We retain the earlier failed local-asymmetry study, all planned checks, code, provenance, figures, and reproduction instructions.

human neuroscience · SEEG · fMRI · sleep · spatial coupling · phase reference · cross-modal testing