One-subject pilot found larger scalp alpha coupling for lateral temporal than hippocampal SEEG
This one-subject pilot tested whether scalp EEG alpha-band power envelopes tracked simultaneous stereo-EEG (SEEG) envelopes beyond shared task-locked structure, and whether coupling differed along one SEEG shaft. We analyzed 16 artifact-free verbal working-memory trials from one patient in OpenNeuro ds004752 version 1.0.1. For the left hippocampal bipolar pair mAHL2-mAHL1 and ipsilateral scalp channel T3, excess coupling (dz) was 0.064 in theta (trial-shift p=0.125), 0.058 in alpha (p=0.0625), and 0.019 in beta (p=0.375). For the lateral middle temporal gyrus pair mAHL8-mAHL7, alpha dz was 0.200 (z=6.08, p=0.0625). Both pairs exceeded all 15 alpha trial-shift values; the lateral pair's alpha effect size was about 3.4 times the hippocampal pair's. The smallest possible shift p-value with 16 trials is 0.0625, so these are effect sizes, not statistically significant findings. The study is a pilot only: N=1, no group inference, and no multiple-comparison correction. Bipolar signals may include nearby sources, and shared muscle, eye-movement, or arousal sources are not excluded. The group hypotheses requiring at least five subjects were not tested.
scalp EEG · stereo-EEG · hippocampus · temporal cortex · alpha band · envelope coupling · verbal working memory · trial-shift null · single-subject pilot
References
4- usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9
The iEEG census identified ds004752 as an OpenNeuro dataset with SEEG-typed channels and simultaneous scalp EEG; we used it to select the dataset.
- supersedesIn one ds004752 patient, scalp T3 tracked lateral temporal alpha power above the trial-shift null, while hippocampal coupling remained small and below threshold sci:sha256:fa7c861e803c9bf3006b5c8b904fec04053acf022c957790d49b2c1214718654
v1 title said hippocampal-scalp coupling was not above the trial-shift null; in alpha it was above all 15 shift values (p_shift 0.0625, same as the lateral pair). v2 states the result as effect sizes. Data, code and numbers are unchanged.
- usesdoi:10.18112/openneuro.ds004752.v1.0.1
The analysis used selected channels and trials from OpenNeuro ds004752, version 1.0.1.
- doi:10.7554/eLife.78677
Cited by
1 publicationPublic catalog entries on Sciscape.
- supportsScalp T3/T4 alpha-envelope coupling increased with lateral position within SEEG shafts in 10 patients
Same 1-patient pilot result (lateral alpha coupling 3.4 times hippocampal). This work extends it to 10 patients. Note: in the first 78 s of continuous data, the sub-01 mAHL shaft alone gave rho 0.0.