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q-bio.NC · Neurons and Cognition

In 34 adult HUP patients, first seizures matched the clinician SOZ better for gamma AUC (+0.090, Holm p=0.006), opposite to a pediatric result

This preregistered replication tested whether the earliest archived seizure gives a lower early-ictal seizure onset zone (SOZ) AUC than later seizures, as reported in 16 pediatric patients in an earlier study. We analyzed archived per-pair, per-seizure features from 34 adult HUP patients with at least two usable seizures; no new EEG data were read. Seizures were ordered by run number, assumed to be recording order. For line length, the first-seizure AUC minus the mean of later-seizure AUCs was +0.056 (95% CI +0.006 to +0.110; p=0.041; Holm p=0.082). For 30–100 Hz power ratio, it was +0.090 (95% CI +0.039 to +0.145; p=0.002; Holm p=0.006). The line-length confidence interval excludes the earlier estimate of −0.105, so that deficit did not replicate and the effect direction was opposite. A three-seizure average line-length map did not show a significant gain (+0.023; 95% CI −0.007 to +0.053; Holm p=0.155). Exploratory tests found no difference between seizures 2 and 3 and no positive order effect for pre-ictal gamma power. These results do not establish a general seizure-order effect: the cohorts differed in age, features, pair definitions, and SOZ labeling practice. A possible circularity in labels based on the first recorded seizure was not tested.

stereo-EEG · seizure onset zone · seizure order · AUC · epilepsy · replication · HUP · OpenNeuro

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References

3
  1. usesIctal gamma power marks clinician-labeled seizure onset zones in 36 SEEG patients, but does not outperform interictal markers sci:sha256:ecd667b57634fb1e817e7d5fe6d4c441d19835f37193438c8474d97fc55b4571

    All input features (per-pair, per-seizure ictal ratios and SOZ labels) come from the archived results of this package.

  2. supportsIctal high-frequency power identified clinical SOZ channels in the first seizure, but its advantage did not replicate sci:sha256:f5d23542d59d9a29ca82001abbb12da78d9ae48fb56dcf2f894156ea6b7c44b2

    With a pre-registered test over 34 patients and 3 seizures, the first HUP seizure gives a higher SOZ AUC than later seizures, as the run-01 vs run-02 difference in this work suggested.

  3. challengesIn 16 pediatric SEEG patients, the earliest archived seizure had lower SOZ AUC than later seizures, while averaging three seizures added 0.027 AUC sci:sha256:5c29e2c477e978bbeb41cef5297642973c6d53ccfd12457ebe7fe6f3c9fdb2cc

    The same first-seizure test in an independent adult cohort gave the opposite sign (+0.056 line length, +0.090 gamma), and the CI excludes the -0.105 estimate.

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