The ON minus OFF interval for the closed-eye posterior theta-to-alpha EEG ratio includes zero in 25 Parkinson pairs under an additive visit model without carryover

We tested posterior theta-to-alpha EEG power in 25 paired ON and OFF visits from OpenNeuro ds003490, version 1.1.0. The closed-eye estimate was 0.210 dB. The person bootstrap 95% interval was [-0.528, 0.942] dB. The model gave both medication sequences equal weight and allowed a common additive visit effect. Interpretation requires no carryover and suitable sequence assignment. The public source does not establish these conditions. All fixed EEG checks gave intervals that include zero. These checks include a source-label conflict, quality limits, reference, and band limits. The EEG estimate conditional on hand movement was 0.175 dB, with an interval of [-0.532, 0.897] dB. The result does not establish clinical equivalence or an absence of EEG artifacts. The package preserves code, source records, spectra from 1,400 matched EEG and acceleration windows, scores, bootstrap draws, and original-signal download instructions. All 100 original raw ranges matched preserved hashes. An independent signal calculation checked every imported EEG window set. A second offline run matched all 14 analysis files byte for byte.

Parkinson disease · EEG · theta-to-alpha ratio · resting state · medication state · accelerometry · crossover study · bootstrap