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q-bio.NC · Neurons and Cognition

Open-loop 50 Hz stimulation did not change cued recall in 20 PAL2 subjects; only 6 had MTL depth contacts

We analyzed 3,330 tested word pairs from 20 subjects and 26 sessions in RAM PAL2 (OpenNeuro ds005494). Within each subject, recall of stimulated and non-stimulated items was compared in lists with encoding stimulation and in lists with retrieval stimulation. Open-loop 50 Hz stimulation had an encoding effect of -3.4 recall points (95% CI -8.7 to +1.1; Holm p = 0.430; 13 of 20 subjects had a negative effect). The retrieval effect was -1.7 points (95% CI -6.1 to +2.4; Holm p = 0.460). Position-matched contrasts, list-level contrasts against no-stimulation lists, and leave-one-subject-out analyses showed the same null result. The dataset README describes hippocampal and entorhinal stimulation, but electrode tables place only 6 stimulation pairs on medial temporal lobe depth contacts. In that subgroup, the encoding effect was -7.7 points (95% CI -20.6 to +1.9; n = 6), which is too small a sample to confirm a site-specific effect. Recall was near floor in 7 subjects and near ceiling in 3, limiting sensitivity in those subjects. Stimulation amplitudes varied from 0.5 to 3.5 mA, but parameters did not vary within subject, so dose effects could not be tested.

paired-associate memory · cued recall · open-loop stimulation · encoding · retrieval · intracranial stimulation · PAL2 · null result

Admitted 2 citing publications

References

4
  1. usesIn 28 patients, open-loop SEEG stimulation at encoding was associated with 2-point lower recall of stimulated words and no impairment above 5 points sci:sha256:ed3152e6018f151b69770c848513cde2fa573f1485fc42fae7f0244cc8317e65

    FR2 encoding-stimulation item contrast. We applied the same stimulated-vs-non-stimulated item contrast to PAL2, and also tested retrieval stimulation.

  2. usesRAM catFR2 did not resolve exploratory hippocampal stimulation or amplitude effects sci:sha256:d0c75680cf7c36672cac5e57ac49f690c715517fc60f1f18996a226096e117fe

    catFR2 hippocampal encoding-stimulation result. We compare the PAL2 MTL-depth subgroup direction with it.

  3. usesHippocampal SEEG stimulation reduced item recall by 11.5 points in five independent participants, but the result was not confirmed sci:sha256:ffc0b64736b4e9d04b20d048956f4fff6b92deafca718faf0b968dd2c4b95d70

    That work used 1 PAL2 subject (R1003P, encoding effect -0.020). We get the same value for R1003P and extend the PAL2 test to all 20 subjects. Here the group encoding effect has the same sign but is not significant.

  4. usesdoi:10.18112/openneuro.ds005494.v1.0.1

    The analysis uses the events, channels, electrodes, participants, and dataset-description files from this exact recorded release of the RAM PAL2 dataset.

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