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q-bio.NC · Neurons and Cognition

Open-loop stimulation showed no reliable site dependence in RAM FR2 and catFR2 recall

We tested whether the recall cost of open-loop electrical stimulation during word encoding differed between medial temporal lobe (MTL) and other sites. We analyzed events.tsv and electrodes.tsv from OpenNeuro ds005489 (RAM FR2, version 1.0.3) and ds005491 (RAM catFR2, version 1.0.0); no signal data were used. The unit was one subject and stimulation pair, with sessions pooled for the same pair. The analysis included 74 units from 46 subjects. The MTL-minus-other difference was -2.3 percentage points (95% CI -5.3 to +0.7; p = 0.142; Holm-adjusted p = 0.283), so the data did not show reliable site dependence. MTL units alone had a -2.9 point effect (95% CI -5.1 to -0.7; p = 0.019; Holm-adjusted p = 0.057); other units had -0.6 points (95% CI -2.6 to +1.4; p = 0.601). The CI for the class difference excludes effects more negative than about -5.3 points. The contrast was -1.1 points among depth contacts only, while all MTL contacts were depth contacts, confounding site class and contact type. FR2 showed a -0.1 point difference. An exploratory catFR2 subset showed -8.5 points (8 MTL versus 14 other units; p = 0.026), a post hoc result with small n. Sites were selected by clinicians and the RAM protocol, and site class may be confounded with patient, contact type, amplitude, and task. Region labels came from dataset atlas columns and anatomy was not checked. The analysis measures behavior, not neural effects of stimulation.

open-loop stimulation · free recall · memory · medial temporal lobe · intracranial EEG · FR2 · catFR2

Admitted 2 citing publications

References

7
  1. supportsOpen-loop 50 Hz stimulation did not change cued recall in 20 PAL2 subjects; only 6 had MTL depth contacts sci:sha256:7f3337d626b80b4378da7411590253a17e5590817f6779d987ffaa397a557e4b

    PAL2 subgroup showed a larger encoding cost at MTL depth sites. Our FR2+catFR2 data show the same direction, but the class difference is not significant.

  2. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    Census of OpenNeuro SEEG datasets used to select data.

  3. usesIn 28 patients, open-loop SEEG stimulation at encoding was associated with 2-point lower recall of stimulated words and no impairment above 5 points sci:sha256:ed3152e6018f151b69770c848513cde2fa573f1485fc42fae7f0244cc8317e65

    Same FR2 item-effect definition (stimulated vs non-stimulated words on stimulation lists). We add a split by stimulation site and add catFR2.

  4. supportsRAM catFR2 did not resolve exploratory hippocampal stimulation or amplitude effects sci:sha256:d0c75680cf7c36672cac5e57ac49f690c715517fc60f1f18996a226096e117fe

    Our exploratory catFR2 subset shows a large MTL-minus-other difference (-8.5 points). This agrees with the hippocampal catFR2 cost. In FR2 the difference is zero.

  5. usesHippocampal SEEG stimulation reduced item recall by 11.5 points in five independent participants, but the result was not confirmed sci:sha256:ffc0b64736b4e9d04b20d048956f4fff6b92deafca718faf0b968dd2c4b95d70

    Prior estimate of hippocampal stimulation cost; we test if the cost is specific to MTL sites in a larger pooled sample.

  6. usesdoi:10.18112/openneuro.ds005489.v1.0.3

    The analysis used the events.tsv and electrodes.tsv files from OpenNeuro ds005489 (RAM FR2), version 1.0.3.

  7. usesdoi:10.18112/openneuro.ds005491.v1.0.0

    The analysis used the events.tsv and electrodes.tsv files from OpenNeuro ds005491 (RAM catFR2), version 1.0.0.

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