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q-bio.NC · Neurons and Cognition

N1 latency rises with distance at SEEG and ECoG contacts in one dataset

In an OpenNeuro dataset with expert-checked N1 peaks, N1 latency increased with distance at both SEEG depth contacts and ECoG surface contacts. Across 8 SEEG patients, the mean per-patient OLS slope was 0.487 ms/mm (95% CI 0.23 to 0.78; 7/8 positive; Holm-adjusted p = 0.023). Across 5 ECoG patients, it was 0.488 ms/mm (95% CI 0.37 to 0.66; 5/5 positive; Holm-adjusted p = 0.0625, the minimum attainable with 5 patients). The difference was -0.001 ms/mm (p = 0.47), so this dataset does not show a smaller depth-contact slope. Theil-Sen gave a smaller SEEG slope (0.232 vs 0.538 ms/mm; uncorrected p = 0.002); SEEG latencies occur in 0.49 ms steps, producing many ties, and two patients had a median slope of zero. The analysis used 3,302 SEEG and 3,147 ECoG N1s from one center, with no patient recorded in both modalities. Detection thresholds differed (3.5 vs 2.6 SD), and the 10–100 ms detector window truncates latency. Distance was Euclidean in native space, not fiber path length. These findings do not establish a conduction mechanism or show that the result generalizes beyond this dataset.

N1 latency · cortico-cortical evoked potentials · SEEG · ECoG · intracranial EEG · electrical stimulation · brain-computer interface · distance dependence

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References

4
  1. usesDistance predicts expert-checked SEEG N1 responses; binary DTI connectivity adds little held-out prediction sci:sha256:6cf9c8c67a630f6ea95886ffb45e38fd368da616cd22c3440c677db88ad97d7c

    We used its archived ds005448 inputs (N1sChecked.mat, electrodes.tsv, S3 provenance with MD5) and its numpy MAT v5 reader (matv5.py).

  2. challengesSEEG depth-contact N1 latency did not scale with distance in 16 patients, while ECoG latency did sci:sha256:031d9f87afdb8fdcda1322161e7bf3d9e51b599fc17dc7316585c54dbe603c92

    64345c41 found no latency-distance slope at SEEG depth contacts in ds004080 (0.11 ms/mm), but 0.39 ms/mm at ECoG contacts. In ds005448, with one pipeline and expert-checked N1s, the depth slope (0.49 ms/mm, 7/8) is equal to the ECoG slope (0.49 ms/mm; difference p = 0.47). Thus the smaller depth slope is not a general depth property. This agrees with the detector explanation that 64345c41 gives.

  3. supportsIn eight SEEG patients, N1 peak latency rose 0.23 ms/mm with distance, but distance explained little variance sci:sha256:a220c79e2df24e0c1e5f59dbea9db64393b61f4a08e653569d6beeb8386ca682

    Our per-patient Theil-Sen mean SEEG slope in ds005448 (0.23 ms/mm, 6/8 positive, 2 at 0) and OLS slope (0.49 ms/mm, 7/8) agree with its positive latency-distance slope (0.23 ms/mm). We add a same-dataset ECoG comparison.

  4. usesdoi:10.18112/openneuro.ds005448.v1.0.0

    The analysis used expert-checked N1 peak files and electrode coordinates from OpenNeuro ds005448 v1.0.0 (STReEF); the archived provenance records file keys, ETags, and matching local MD5 hashes. The exact version metadata records CC0.

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