Four early pulses selected larger later responses at five SEEG contacts within each recording with the source reference

This study tested whether four early pulses could select stimulation sites with larger later SEEG voltage responses. It used OpenNeuro ds004457, version 1.0.2, with one fixed contact in each of five patients. The first four and last four clean pulses were separate. The analysis retained 161 site and patient pairs. With the source reference, rank correlation ranged from 0.441 to 0.766. Selecting the largest fifth of early scores gave a mean later response ratio of 2.359, with equal patient weight. Pre-pulse mean rank correlation was 0.137. In patient 5, adjacent bipolar recording reduced rank correlation from 0.766 to 0.154. The result applies within each source recording. It does not show next-day performance or clinical benefit. The package contains five figures, pulse epochs, code, results, source hashes, and reproduction instructions. A repeat analysis in a standard virtual environment gave identical numerical tables.

stereoelectroencephalography · electrical stimulation · response calibration · site selection · intracranial EEG · pulse response · recording reference