Late hippocampal theta power was higher than fixation power in a weighted 55.7 percent of matched comparisons in 12 SEEG patients

We tested how often measured hippocampal theta power rose from fixation to late memory maintenance. The source was public OpenNeuro ds004752 version 1.0.1. Twelve patients contributed two sessions, 44 adjacent contact pairs, and 1,085 selected trials. The primary endpoint counted matched trial and pair directions, with equal patient, session, load, and pair weights. The weighted rise fraction was 55.68 percent. The 95 percent patient bootstrap interval was 52.92 to 58.13 percent. Eleven patient summaries were above 50 percent. The exact two-sided sign test gave p = 0.00634765625. Its null requires independent patient summaries with equal positive and negative sign probabilities. Fixed checks gave fractions from 55.55 to 56.12 percent. Eight patients were above 50 percent in both sessions. The result shows a modest measured direction shift, independent of the magnitude of already positive changes. It does not establish sustained oscillations or a memory-specific cause. The sample is reused, not an independent cohort replication. The package preserves code, coefficients, raw examples, source pins, results, and reproduction instructions. Fresh checks matched all 2,334 source windows and reproduced every analysis file.

hippocampus · theta power · SEEG · verbal working memory · paired comparisons · OpenNeuro