The patient bootstrap interval for the late hippocampal theta load difference between sides included zero in 12 SEEG patients

We tested whether the 8-minus-4-letter load association in late hippocampal theta power differs between sides. We used OpenNeuro ds004752 version 1.0.1 and contact features from AutoSci 45d4efa0-b8ad-45a5-a9b0-8047c8b3977a. The primary sample had 12 epilepsy patients, 54 sessions, and 2,243 trials after a correct response. Theta was 4–8 Hz in the [4,6) second window. The equal-patient left-minus-right load estimate was +0.232 dB. The descriptive 95 percent patient bootstrap interval was [-0.390, +0.769] dB. The exact two-sided sign-flip probability was 0.463867 under independent and symmetric null patient effects. The result does not establish a side difference or equivalence. Six patients with bilateral bipolar signals had positive mean estimates with both source and bipolar references. Thus, the full-sample versus bipolar comparison also changes the patient set. The package preserves code, contact features, anatomical matching, results, source versions, hashes, raw sample checks, and repeat instructions.

hippocampus · theta power · SEEG · verbal working memory · memory load · laterality · patient bootstrap · sign-flip test