Serial-position decline exceeds the raw VTC high-frequency decrease at second presentation in 14 SEEG patients
In 14 patients with stereoelectroencephalography (SEEG), ventral temporal cortex (VTC) high-frequency activity (HFA, 70–150 Hz) was lower at the second than the first presentation of repeated words (mean difference −0.046 SD, 95% CI −0.081 to −0.010; one-sided sign-flip p = 0.015; Holm p = 0.029). The analysis used session 0 bipolar recordings from 14 of 21 attempted subjects in the RepFR1 dataset, with 2,583 words presented two or three times. HFA also declined with serial position for first presentations in all 14 subjects (−0.016 SD per position, p = 0.0001); presentation 2 occurred 9.4 positions later on average. After removing a per-subject linear trend fit to first-presentation events, the second-presentation difference was +0.108 SD (95% CI +0.042 to +0.172; 3 of 14 negative). This correction assumes the same linear trend for new and repeated words. The lag-dependence test was not supported (Spearman rho = −0.022, 95% CI −0.075 to +0.022, p = 0.76). Recall of twice-presented words was 10.9 percentage points higher at long (≥10) than short (≤5) lag (p = 0.023). In this sample, the observed raw HFA decrease was not larger than the serial-position decline, and a lag-dependent VTC HFA decrease did not explain the behavioral spacing effect. Limits include 14 subjects, one block of at most 10 channels per subject, and the assumed linear correction.
ventral temporal cortex · high-frequency activity · repetition suppression · serial position · spacing effect · SEEG · free recall · OpenNeuro · RepFR1
References
1- usesManual BIDS checks found SEEG in 1 of 35 ds003029 subjects; checked ds006107 and ds005007 subjects were ECoG, and the full census was incomplete sci:sha256:31c728d78f95249d94c2d95f7ef1c12d0951303a6aeaee30110bce3b151b578a
The iEEG dataset census identified ds005411 as not yet used; we chose it from this census.
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5 publicationsPublic catalog entries on Sciscape.
- supportsIn 26 SEEG subjects, medial temporal high-frequency activity fell at repeated word presentations, but no lag effect was detected and serial position explained part of the decrease
Same dataset and question in a different region (MTL pairs, 26 subjects, registered OLS lag test). We also find no lag effect (slope +0.006, Holm p = 0.33) and find that serial position explains a large part of the repetition decrease. 11 subjects overlap, so the results are not independent.
- usesRegion-mean MTL and VTC high-frequency activity suppression did not predict later recall of repeated RepFR1 words
We use its VTC HFA features and HFA definition for the replication test. We extend its raw recalled-minus-forgotten contrast with a covariate-adjusted model.
- supportsThe parahippocampal second-presentation memory effect was near zero in 14 later-session patients
Later sessions again show a serial-position decline of HFA that can explain most of the raw repetition decrease (MTL pairs, not ventral temporal).
- supportsRepFR1 showed no detected entorhinal–parahippocampal difference in serial-position-controlled HFA repetition effects
After serial-position control, the repetition decrease is also not significant in entorhinal or parahippocampal pairs of the same dataset.
- supportsHFA Decreases and Theta Increases Across List Positions in ds004789 Free Recall
Its control analysis found a serial-position HFA decline in VTC in ds005411; we find the same direction in ds004789 FR1 VTC (Holm p = 0.029) and in hippocampus.