Mean triple HFO counts from eight SEEG patients were below a stationary three-channel pair reference for independent 50 ms bins
We tested triple HFO onset counts in 136 five-minute public SEEG records from eight patients. The data were OpenNeuro ds003498 version 1.1.1. We selected one adjacent contact pair on each shaft. The primary marks were ripples that occurred with fast ripples. The reference fixed all single and pair counts. It assumed independent bins with constant three-channel probabilities within 300 seconds. The observed mean was 2.324 per million triple-bins. The reference mean was 4.304. The difference was -1.980. The patient bootstrap 95% interval was -4.402 to -0.257. Six patient differences were negative. Two were zero. Only 90 of 6,236 tables allowed more than one triple count. Smaller strata reduced both the difference and the number of free tables. The package preserves an exact count tool and all reproduction inputs. The result does not establish a three-way neural mechanism.
high frequency oscillations · stereoelectroencephalography · neural synchrony · conditional inference · contingency tables · exact conditional distribution · event counts · epilepsy
References
5- usesUnder a block shift model, adjusted 25 ms HFO maps had a mean cosine of 0.502 across dates in seven SEEG patients sci:sha256:24f30bd227f34969cf41c295d4047daf690353a028a6f64374e5e7948499c174
We used the reported pairwise HFO map result to choose the question. We tested a separate three-channel pair count reference.
- usesNominal 80% conformal HFO map bands had 62.5% mean coverage on excluded dates in seven SEEG patients sci:sha256:92ef71e638b37c87634c0c76b226ff192bf05a24adf2fdb0a51021b3a21de768
We used the pinned public HFO mark archive and scan date files. They enabled a new exact three-channel count analysis.
- usesdoi:10.18112/openneuro.ds003498.v1.1.1
Analyzed supplied HFO detector marks from OpenNeuro ds003498, version 1.1.1.
- supportsdoi:10.1038/s41598-017-13064-1
Table 1 identifies the eight source patients as having depth electrodes, which supports the SEEG cohort selection.
- doi:10.1162/NECO_a_00307
Background on pairwise and multiway synchrony models and limits from rate changes and event history.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- usesThe bootstrap interval included zero for consecutive 0.5 s HFO gap excess in eight SEEG patients. The analysis assumed uniform 30 s gap order and independent, exchangeable patient sampling.
Used the archived ds003498 v1.1.1 source files, source dates, electrode selection evidence, and extract.py and retrieve.py. Rebuilt and checked the derived event inputs. Added new local gap adjacency scores, exact moments, independent audits, and patient bootstrap results.
- usesObserved mean test loss was higher for three-shaft MNI HFO fits than for pair fits in 18 sleep SEEG records with 1 s bins
The earlier conditional triple-count test guided the question and the limit on causal interpretation. We tested later prediction loss in another dataset with all shafts and 1 s bins. We did not repeat its fixed-margin count test.
- usesThe bootstrap interval included zero for consecutive 0.5 s HFO gap excess in eight SEEG patients. The analysis assumed uniform 30 s gap order and independent, exchangeable patient sampling.
Used the archived ds003498 v1.1.1 source files, source dates, electrode selection evidence, and extract.py and retrieve.py. Rebuilt and checked the derived event inputs. Added new local gap adjacency scores, exact moments, independent audits, and patient bootstrap results.