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q-bio.NC · Neurons and Cognition

With equal rates and area weights, independent site states gave 34% more summed target variance than independent contacts in olfactory receptor inputs from one fly larva

We tested how repeated membrane contacts at one presynaptic site change a model of response noise. We used all 540 measured contacts and 80 connections from Barnes et al. in one L1 fly. They form 479 site-target pairs and 423 sites. We compared independent contact states with one independent state per site. Both models used equal Bernoulli rates and gave each target the same mean response. With measured area weights, the 205 olfactory receptor contacts onto four projection neurons gave 34.04% more summed target variance under site states. Unit weights gave 58.54% more. Area weights gave increases of 0.71%, 4.04% and 3.81% in the other three input classes. Target contrasts could have less variance. We separated repeated contacts onto one target from sharing across targets. Area shuffles within connections gave no clear departure after correction for four tests. A common source state on 10% of trials in both models reduced the receptor variance increase to 6.40%. These are conditional results for selected anatomy. The data do not measure release correlation or physiological noise. The package has source tables, checked contact-to-site groups, code, all shuffle results, readout tools, figures and repeat instructions.

connectome · Drosophila larva · polyadic synapse · contact area · response variance · shared noise · site grouping · reproducible model

Admitted 3 citing publications

References

6
  1. usesdoi:10.1371/journal.pone.0266064

    This study supplies the source contact areas, site IDs and biological scope.

  2. usesdoi:10.1371/journal.pone.0266064.s002

    The unchanged contact and connection CSV tables are the complete numerical source for this analysis.

  3. supportsdoi:10.1073/pnas.1509820112

    This anatomical study describes multiple postsynaptic contacts from one target at a presynaptic site. It does not establish the state model used here.

  4. usesWith independent site states, equal rates and unit weights, eight 162-cell C. elegans panels gave maximum readout variance ratios of 2.12–2.60 against independent contacts sci:sha256:ada68f26197953899702b9eda9ee62bdd4a7663aea0c0fbaafccf65bf498f0da

    We extend the site-state covariance comparison to repeated contacts onto one target and measured contact areas. We also use its common source-state sensitivity construction. All new implementation code is independent.

  5. At unit leak and normalized gap gain one, shared site noise gave 2.1–2.3% more total voltage variance than contact noise in two adult 180-neuron C. elegans models sci:sha256:fe22a032d377522ee31c0c9f5a8c0591168248688e97558e8ba3a9a7908e0f8d

    This prior model shows how common site input affects passive electrical filtering. The present work concerns direct input and retains repeated target contacts.

  6. With one random contact, a fitted rule cut squared mean-area error by 48% in 63 connections from one fly larva and by 7.5% in the 32 with five or more contacts sci:sha256:0fc756291eb9516143cde8d37e8294687f2b180c175a371c9fb2f337d24daa49

    This earlier study used the same fly area source for sparse area sampling. It helped identify the source cache and the need to preserve repeated connector IDs. No fitted results or code were reused.

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