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q-bio.NC · Neurons and Cognition

At unit leak and normalized gap gain one, shared site noise gave 2.1–2.3% more total voltage variance than contact noise in two adult 180-neuron C. elegans models

We tested how noise shared at chemical synapse sites changes filtering by electrical connections. We kept all 180 named brain neuron slots in each of two adult C. elegans maps. Both passive models had unit capacitance and unit leak. Unique gap counts set conductance, with median positive degree scaled to one. The site model used independent white noise at each site and unit amplitude at each target. The contact model matched every target noise intensity. At gap gain one, the site model had 2.065% and 2.331% more total voltage variance. Contact noise overstated the fall from the uncoupled level by 1.090 and 1.147 percentage points. Direct electrical neighbors supplied 77.65% and 71.12% of this difference. Electrical difference energy was about 2.3% lower with site noise. A trace identity fixes the sign of the total variance effect under the stated passive and input assumptions with one sign at each site. Common source noise reduced the effect. All listed parameter checks and both maps are retained. A source audit found no additional known neuron among excluded endpoints. Separate covariance solvers, time integration, exact examples, fresh source extraction and an offline repeat checked the calculation. This is an exploratory result for these graph models. Partial electrical annotations and unknown release, receptor and membrane properties limit its biological scope. It does not measure voltage noise or establish a release mechanism. The package preserves code, numerical facts, source hashes, matrices, cell and pair results, figures and repeat instructions.

connectome · C. elegans · polyadic synapse · gap junction · noise covariance · passive network · stationary covariance · structure and function

Admitted 3 citing publications

References

5
  1. usesdoi:10.1038/s41586-021-03778-8

    The two adult site exports, native electrical records and neuron metadata define the anatomical models. We use the pinned repository commit and all eligible named neuronal endpoints.

  2. doi:10.1002/dneu.20307

    Concurrent miniature currents at polyadic neuromuscular junctions motivate a shared site input model. That result does not establish shared release at the brain sites used here.

  3. usesWith independent site states, equal rates and unit weights, eight 162-cell C. elegans panels gave maximum readout variance ratios of 2.12–2.60 against independent contacts sci:sha256:ada68f26197953899702b9eda9ee62bdd4a7663aea0c0fbaafccf65bf498f0da

    We extend its matched site and contact input covariance comparison to stationary passive voltage noise. The extraction and code here are new.

  4. usesWith equal leak and unit normalized gap gain, bilateral pooling reduced input power by up to 12.33% and 14.57% in two passive C. elegans nerve ring models sci:sha256:771a0f97c75be1ab76c078398494fe5e3f14d3606ec8bf220ac1b1a1553575e9

    We use the unit-leak passive network and median positive degree scale as a stated model convention. We use different anatomical inputs and a different output.

  5. With unit weights and free source covariance, two linear input models gave equal covariance on an 81-neuron panel in two adult C. elegans maps sci:sha256:473ffba1f697779e4c002af488e06f8041c313f5f444977db0549f2cc6615780

    The free source covariance result limits identification of a shared site mechanism from target covariance. Our source checks are restricted model cases.

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