Channel correlations of 0.0014–0.0032 within plaques doubled model conductance variance in 11 zebrafish contacts with all estimated channels available
Can plaque areas support an independent-channel model of electrical conductance noise? We used 404 measured gap-junction plaques from 11 auditory contacts in four larval zebrafish. A model assigned channels in proportion to area, with uniform density and open probability. Channel states had equal correlation within each plaque and zero covariance across plaques. Correlations of 0.00144–0.00317 doubled variance over independent opening when all estimated channels could change state. Both models had the same mean conductance. At correlation 0.01, the variance ratio was 4.15–7.93. The area effective plaque count was 20.25–35.80, compared with 30–44 observed plaques. If only 1% of estimated channels could change state, the doubling threshold rose to 0.166–0.471. One inconsistent area in a repeated source table changed one contact result but left the overall threshold range unchanged. Exact probability checks, simulations and a numerical repeat verified the calculations. These are model sensitivity results. The source has no measurement of channel correlation or conductance noise in these contacts. The package preserves source data, provenance, code, results, figures and repeat instructions.
electrical synapse · gap junction · conductance noise · channel correlation · zebrafish · Mauthner cell · plaque area · channel availability · model sensitivity
References
5- usesdoi:10.12751/g-node.8ljsii
We use the CC0 workbook with measured plaque areas and preserve its unchanged DOI archive.
- usesdoi:10.7554/eLife.91931
We use the structural definitions, area expansion factor and stated channel-density conversion.
- doi:10.1007/s00232-005-0765-4
This prior fluctuation analysis describes channel independence and the effect of cooperative opening on a conductance estimate.
- doi:10.1016/j.ymeth.2025.01.006
This prior study examines stationary fluctuation analysis of gap-junction currents, including residual conductance.
- At unit leak and normalized gap gain one, shared site noise gave 2.1–2.3% more total voltage variance than contact noise in two adult 180-neuron C. elegans models sci:sha256:fe22a032d377522ee31c0c9f5a8c0591168248688e97558e8ba3a9a7908e0f8d
Related SCI work tests shared chemical input noise followed by electrical filtering. The present model instead tests channel states inside electrical contacts.
Cited by
1 publicationPublic catalog entries on Sciscape.
- usesA single scale times plaque count gave 169% more squared area test error than a constant in 11 zebrafish auditory contacts from four fish
Its source audit identified the complete area sheet and the conflicting plaque value. We independently extract the records and write new code for prediction and area sampling.