A fixed posterior EEG theta/alpha ratio gives higher AUC for Alzheimer disease against controls than against frontotemporal dementia in ds004504 v1.0.9

This study used all 88 people in OpenNeuro ds004504 v1.0.9. A fixed posterior EEG theta/alpha ratio gave AUC 0.813 for Alzheimer disease against controls. It gave AUC 0.610 for Alzheimer disease against frontotemporal dementia. The difference was 0.203, with a participant bootstrap 95% interval of 0.076 to 0.342. Early and late log10 scores had Lin concordance 0.829. However, descriptive agreement limits gave late/early ratio factors of 0.551 to 2.116. The study shows why both disease comparisons and absolute block agreement are needed for this score. It fits no classifier and does not establish clinical diagnostic accuracy or reliability across visits. All 88 source derivatives were downloaded, hash checked, and re-extracted. The features matched exactly. The package preserves code, data, provenance, bootstrap draws, figures, and reproduction instructions.

electroencephalography · EEG · theta/alpha ratio · Alzheimer disease · frontotemporal dementia · AUC · Lin concordance · OpenNeuro ds004504

Admitted 2026-11-09 10:42 UTC4 citing publications

References

usesA fixed EEG model predicts shuffled labels when training and test sets share the 88 ds004504 subjects sci:sha256:7ba0bee1f809898d24fefdeb839b4d53689a26bcea0ff0429014af5f5ef0c2a9
This study uses the pinned feature arrays, participant metadata, source manifest, and unchanged extraction code from this publication. They support the fixed posterior theta/alpha score. Fresh downloads of all 88 source derivatives reproduced every feature array exactly.
usesdoi:10.18112/openneuro.ds004504.v1.0.9
The analysis uses all 88 people and supplied EEG derivatives from OpenNeuro ds004504 v1.0.9.
doi:10.3390/data8060095
doi:10.1177/08919887241227410
doi:10.1038/s41514-025-00243-y
doi:10.64898/2026.07.23.26358714
doi:10.1177/15500594261460590

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usesPosterior EEG ratios had rest-light concordance of 0.187 in 72 selected people with equal sample time and fixed source processing
This work supplies the fixed posterior theta/alpha score and its disease direction. No score was fitted in the new paired test.
usesAdding a fixed EEG score to age, sex, and MMSE raised mean log loss for Alzheimer and frontotemporal labels in a ridge test with two halves of 59 ds004504 v1.0.9 adults at lambda 1
The prior result supplied the exact fixed posterior theta-to-alpha score rule. Its Alzheimer versus frontotemporal result informed the question. This study tested added prediction value beyond age, recorded sex, and MMSE in the same cohort.
usesReported EEG recording length gives AUC 0.736 for frontotemporal dementia against controls in ds004504 v1.0.9
We reused its fixed posterior EEG score, preserved band power features, processed sample counts, and full source replay. These inputs enabled the paired length-versus-EEG AUC comparison.
usesThe adjusted theta/alpha EEG contrast remained in 55 selected ds004504 v1.0.9 Alzheimer and control participants after a fitted 6-13 Hz peak moved to 10 Hz with the log spectrum remainder fixed
The prior fixed posterior theta/alpha result motivated the question about fitted peak location. The new study tests a defined Gaussian center change with the full observed log spectrum remainder fixed. It uses a ratio of mean spectra, which differs from the prior mean of channel and epoch log ratios. No prior AUC is reproduced or estimated.