Cross-pulse energy outside three fitted directions exceeded baseline at 20–100 ms in five SEEG sessions

We tested three response directions fitted with the first four pulses at each of 183 stimulation sites in five public SEEG sessions. The final four pulses measured cross-pulse energy at 20–100 ms. Energy outside three directions exceeded a matched before-pulse control in all five patients. The equal-patient mean difference was 3.83% of fitted template energy. The two-sided patient sign-flip reference was 0.0625. Three directions captured a mean of 95.90% of later energy from differences between sites; residual fractions ranged from 0.22% to 11.39%. All planned checks retained positive patient contrasts. The signal interpretation needs errors with zero cross-pulse covariance. Shared artifacts and drift can remain. The result applies to these sessions and does not establish brain control or a population effect. The package includes code, data, figures, a pinned source recipe, and checks of all ten rebuilt input files.

stimulation · SEEG · ventral temporal cortex · cross-pulse energy · response directions · signal dimensions · epilepsy · neuroscience