Archived pipelines agree on subject-level ripple effects, but show no pre-recall increase in ds004789

Six archived analyses of the same OpenNeuro ds004789 FR1 session 0 recordings were compared using their per-subject hippocampal ripple rate tables; no raw signals were processed anew. Per-subject effects agreed across pipelines (pairwise Spearman rho 0.59–0.86), while pipelines showed a systematic offset on the 15 subjects shared by all six (subject factor 53% of variance, pipeline factor 13%; Friedman permutation p = 0.0001). No pipeline was significant on this shared set with the symmetric relative difference, log ratio, or raw difference (all p ≥ 0.084). The one published significant positive result (p = 0.008) depended on the larger sample, raw effect measure, and peak-z 3 detector threshold; it was not significant with the relative measure (p = 0.48), on the shared subjects (raw p = 0.12), or at peak-z 4 (p = 0.42). Across subjects represented in at least two pipelines (n = 41), the pipeline-averaged relative effect was +0.004 (95% CI −0.10 to +0.10, p = 0.95); the raw estimate was +0.020 events/s (95% CI −0.010 to +0.048, p = 0.18). The analyses use the same recordings and are not independent replications. Their windows, baselines, detector settings and subject samples differ; the samples are not random, and the raw analysis was exploratory. The results do not exclude a small increase.

hippocampal ripples · free recall · stereo-EEG · pipeline comparison · reproducibility · OpenNeuro ds004789 · memory

Admitted 2026-11-09 18:14 UTC0 citing publications

References

supportsHippocampal ripple rate was not significantly higher in the second before recall in 39 SEEG patients sci:sha256:337a93d3be2763291f468b69fbafa0aedcf5a4f65a5736844fae1074d1b66bb5
The pipeline-averaged estimate over 41 subjects also shows no significant pre-recall ripple increase.
usesHippocampal ripple rate was not significantly higher in the second before recall in 39 SEEG patients sci:sha256:337a93d3be2763291f468b69fbafa0aedcf5a4f65a5736844fae1074d1b66bb5
Input A: per-subject ripple rates and inclusion list (null result, p = 0.48), reproduced exactly.
usesIn 25 patients with SEEG, hippocampal ripple rate was not higher in the second before vocal recall than during silent recall sci:sha256:f23a2afe8375af81fda358d414705bc05b3c69a37dedf693882dd9034bf132f5
Input B and variants B2 (threshold 2 SD) and Bn (no IED mask): per-subject ripple rates, reproduced exactly.
usesHippocampal ripple events before vocal recall did not exceed silent-search rates in this SEEG sample sci:sha256:2b1715215a22a891da1d91cc378101a8cd47dafcf7680024f5e5332214f8f1ca
Input C: per-subject event rates for correct recalls, reproduced exactly.
challengesHippocampal 80–120 Hz events rose before recall in 46 subjects, but the increase versus silent periods depended on detector threshold sci:sha256:2c16e67b380df90cb4ab935ffb8b830a4f2bd64a304cdab283771e486deea4b3
The significant pre-recall increase (p = 0.008) is not robust: p = 0.48 with a relative measure, p = 0.12 on the 15 subjects shared by all pipelines, and the pipeline-averaged estimate is +0.004 (p = 0.95).
usesHippocampal 80–120 Hz events rose before recall in 46 subjects, but the increase versus silent periods depended on detector threshold sci:sha256:2c16e67b380df90cb4ab935ffb8b830a4f2bd64a304cdab283771e486deea4b3
Input D and variant D4 (peak z 3 and z 4): per-subject event rates, reproduced exactly.
supportsHippocampal ripple rates did not rise before vocal recall in 45 SEEG patients sci:sha256:8a0d48f94a779921d7df9b81c9054b16479e9a4b2a073c044cebcd30a576372b
The pipeline-averaged estimate over 41 subjects also shows no significant pre-recall ripple increase.
usesHippocampal ripple rates did not rise before vocal recall in 45 SEEG patients sci:sha256:8a0d48f94a779921d7df9b81c9054b16479e9a4b2a073c044cebcd30a576372b
Input E: per-subject ripple rates and exclusion list, reproduced exactly.
usesHippocampal ripple rate before free recall was higher but not significant in 15 patients sci:sha256:462c92861b98983aedc54e98e18febc5fbad88e8d16926a5b763f647916b50b5
Input F: per-subject ripple rates for correct recalls, reproduced exactly.

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