Adding a term for paths in either adult worm raised test Brier error in a fixed model of 8,008 C. elegans atlas pairs
We tested whether short paths found in an individual adult map improve response prediction beyond paths in a pooled connectome. We used two adult C. elegans maps and the Randi signal propagation atlas. The full join had 15,384 measured pairs. The main test kept 8,008 pairs with a pooled two-step route and no direct edge. Responses were detected in 425 of 7,527 pairs with a path in either adult and 18 of 481 pairs that required pooling. A fixed logistic model controlled for trial count, route count, connection type, neuron degree, reverse edges, bilateral identity, and soma distance. Five-fold tests excluded stimulated neuron classes. Adding a term for a path in either adult raised Brier error from 0.0475173 to 0.0475304. The gain was -0.0000131. Its central 95% node-resampling range was -0.0000878 to +0.0000357. The range is conditional on fixed atlas summaries and fitted predictions. It is not an animal confidence interval. Source version and stricter endpoint checks gave similar small changes. Responding-class tests gave a small positive Brier gain. The adjusted odds-ratio range was wide, so the result does not establish equal function or zero association. A separate check used four anatomical tables on 300 neuron labels. Source matrices remain external. The package preserves code, hashes, model states, predictions, losses, figures, and rebuild instructions. Independent graph and likelihood checks passed. A fresh-source rebuild matched all 28 result files and four supporting figures.
connectome · Caenorhabditis elegans · signal propagation · graph aggregation · path provenance · optogenetics · prediction benchmark
References
8- usesThe union of two adult C. elegans brain maps gave paths of at most two edges for 1,102 neuron pairs with no such path in either map sci:sha256:fa0ea4c43e02533a5f18b5a255a13297792c2b49c443ef165f63ecefeeababae
We reuse its 180-neuron reference table and reproduce its original chemical path census. We extend the question to measured signal responses.
- Stable chemical connections across eight C. elegans connectomes did not propagate optogenetic signals more often than variable connections at matched adult synapse count sci:sha256:5cbb4c1917dff79c9e9f17c6ff6ae5d0ba556de73d1a96c2f13df319c7fef4d0
This prior analysis joins anatomical connection stability with the same response atlas. We test short-path provenance instead.
- usesdoi:10.1038/s41586-023-06683-4
This study supplies the optogenetic signal propagation measurements and detection criteria.
- usesdoi:10.1038/s41586-021-03778-8
This study supplies the two adult brain maps and the source brain cell panel.
- doi:10.1103/6wgv-b9m6
This prior study compares anatomical and signal propagation network structure.
- doi:10.48550/arXiv.2006.15401
This prior work explains how graph aggregation can create paths. The general aggregation problem is established.
- usesdoi:10.1098/rstb.1986.0056
White anatomical data in the pinned wheel supply the broader reference check.
- usesdoi:10.1371/journal.pcbi.1001066
The broader reference uses the whole-worm anatomical compilation included in the pinned atlas wheel.
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