The union of two adult C. elegans brain maps gave paths of at most two edges for 1,102 neuron pairs with no such path in either map
We tested how edge pooling changes short paths in two adult C. elegans brain maps from Witvliet et al. (2021). We used directed chemical connections among 180 neurons. At a limit of two edges, the union graph reached 14,574 ordered neuron pairs. Of these, 1,102, or 7.56 percent, had no path within that limit in either adult graph. All 1,102 had a longer route in at least one adult. Each adult reached the same 7,826 pairs within two edges. The common-edge graph reached only 6,135, a loss of 1,691 pairs, or 21.61 percent. For 1,368 missed pairs, neither adult had a direct edge. The two maps provided routes through different intermediate neurons. Both effects remained at higher count cutoffs and in smaller neuron panels. We supply a tool that keeps each specimen separate, all pair distances, exact source hashes, code, figures, and repeat instructions. A separate algorithm checked 1,519,152 distance values. Exhaustive tests checked all 4,096 pairs of directed graphs on three nodes at four path limits. Fresh downloads rebuilt the numerical inputs. A local repeat reproduced all eight numerical files and four figure files. The general aggregation problem and layer method are established. This work gives a new quantitative worm benchmark. The results describe two fixed annotation files and binary graph rules. They do not establish neural signal flow, population error rates, or compensation after cell loss.
connectome · Caenorhabditis elegans · graph aggregation · reachability · specimen support · chemical synapses · reproducibility
References
5- usesdoi:10.1038/s41586-021-03778-8
We use the two adult chemical synapse lists and cell metadata from the authors repository at a pinned commit.
- usesdoi:10.48550/arXiv.2006.15401
We apply the established principle of keeping graph layers separate to avoid paths made by aggregation.
- doi:10.3389/fnetp.2024.1457486
This work studies how group connectome rules change structural and model dynamic results.
- usesOne-synapse larval C. elegans edges with mirror support occurred more often in both adult brains after contact and repeat controls sci:sha256:08df70c58a861fdfcd1538a7f77eb6356fa0740d02a245f2304856e7339e919a
We reuse two attributed numerical tables only to check adult counts in its 162-neuron panel. We do not reuse its models or larval outcomes.
- Some shortest paths in the two 8 Å C-alpha ubiquitin majority graphs without added consecutive-residue edges occur in less than half the coordinate models. sci:sha256:6f8250769873563579b0e6af04f51787b840cbb0b7da28ff086bea999dbfbf19
This prior SCI work counted joint support for protein contact paths. It is related work on specimen support. No files are reused.
Cited by
9 publicationsPublic catalog entries on Sciscape.
- usesA fixed model gave a 0.000009 mean Brier gain from two-step electrical paths in 15,384 C. elegans atlas pairs
Its map-pooling audit motivates construction of paths within each exported anatomy map. No edge can switch maps inside a route.
- usesPharynx controls reduced the added prediction gain from indirect walks by 89% in a fixed C. elegans atlas test
Its map-union shortcut result motivated calculation of route scores within each export before averaging. No code or result data were reused.
- A model with no internal axon-to-dendrite transfer lost two-step reachability for 46,259 pairs in one larval fly brain graph
This related study measures path changes from specimen pooling in worm graphs. We test within-neuron arbor aggregation in one fly graph and reuse none of its data or code.
- usesA flag for two-edge chemical routes in an adult map increased Brier error in a fixed model of calcium response detection for 3,293 C. elegans atlas pairs
We test its structural path-pooling question against measured calcium responses. We read its verified publication. No source code was reused.
- Blocking internal axon-to-dendrite transfer kept all reachable pairs and increased 4.15 percent of shortest distances in a 2,952-neuron larval fly graph with all edges
Related SCI work showed that pooling worm specimens can change short routes. We do not reuse its code or numerical data.
- usesAdding a term for paths in either adult worm raised test Brier error in a fixed model of 8,008 C. elegans atlas pairs
We reuse its 180-neuron reference table and reproduce its original chemical path census. We extend the question to measured signal responses.
- usesAdding a count of paths within one map reduced Brier error by 0.000014 in a fixed test of 21,074 C. elegans pairs without recorded direct edges
The source map path question extends its structural audit. We add the functional response benchmark and four-map analysis.
- usesAdult map labels raised Brier error after route count adjustment in 7,554 C. elegans atlas directions
We extend its route audit to measured function. We use its native chemical count extract for a source-version check.
- supportsCombining left and right neurons gave unsupported two-step chemical routes among 162 embryonic neurons in eight C. elegans brain maps
This prior audit measured short routes after pooling edges across two adult animals. The present audit combines neuron labels within each animal. Its 180-neuron adult edge counts also provide a consistency check.