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q-bio.NC · Neurons and Cognition

A 2 µm range model gave 1.28% HVC spine coverage from dopamine contacts on the same MSN and 11.95% from all targets in one Area X export

We tested local access to recorded dopamine contacts in one adult male zebra finch Area X export. We used 8,096 medium spiny neurons (MSNs), 796,003 HVC spine contacts and 85,328 selected dopamine contacts. The main filters required contact area at least 0.1 square micrometres, detection score at least 0.6 and source fragment length at least 50 micrometres. In a static 2 micrometre range model, 1.282% of HVC spine contacts had a dopamine contact on the same MSN within range. Allowing a contact on any selected MSN gave 9.353%. Allowing any target gave 11.952%. An explicit whole-cell access rule would mark 99.137% of HVC sites. Thus, a neuron-level contact and local spatial access gave different model predictions. A target-label reference with fixed counts in 20 micrometre cubes gave mean coverage of 0.161%. Added 2 micrometre cubes gave 1.277%, but 95.3% of nearby site incidences could not change target. The reference does not keep membrane contact opportunity. With the cortical sites fixed, lowering the dopamine area cutoff to 0.02 square micrometres raised same-cell and all-target coverage to 9.047% and 53.585%. These values concern selected contact sites, not measured release or learning. Missing release sites, unknown receptors and automated labels limit biological use. The package contains derived data, figures, exact reference code, every draw, source hashes and repeat steps. Independent checks matched 505 API rows, 750 distance calculations and all six exact reference means.

connectome · Area X · dopamine · song learning · spatial access · medium spiny neuron · local reference · HVC

Admitted 1 citing publication

References

7
  1. usesdoi:10.1101/2025.10.25.684569

    This study supplied the j0251 Area X connectome. We used the public v8 arrays and the API.

  2. doi:10.1101/2020.02.18.954354

    The study of local credit assignment links HVC spine input, LMAN shaft input and a dopamine signal in an MSN model.

  3. doi:10.1126/sciadv.aei0203

    This study measured local dopamine release and receptor appositions in mouse preparations. It motivates a spatial access question but does not set a measured range for this bird.

  4. doi:10.1038/s41467-025-66355-x

    This study examined the spatial relation of dopamine varicosities and cortical-striatal synapses in mouse material.

  5. In one Area X volume, mean HVC–LMAN coverage at 5 µm was 7.7% by skeleton path and 15.0% by Euclidean distance in 186 MSNs sci:sha256:86d2b3a93d8c20916ea088fec677bf94215b6ec26d1b66d14c5e9a917c83ba30

    This prior study measured local HVC to LMAN coverage on MSN dendrites. We ask a separate question about dopamine contact sites and target identity.

  6. A 20 micrometre control reduced HVC route excess from 98% to 1.2% in one songbird Area X volume sci:sha256:c72fad3d2fdbcadfd43638110bb25b29f77338c9031619640f003ef00d4c639e

    This prior study showed the effect of local count controls on an HVC route test in the same source export. It motivated local rather than global target-label controls.

  7. In one Area X v8 export, keeping distinct partners raised GPi preference excess from 1.58 to 5.88 percentage points under 20 micrometre count controls sci:sha256:2e2b1d2b357c913059851709855a29b27cf72bb6b0230fe570ea022fa9ff3094

    This study showed that contact and partner constraints can change a count reference in the same export. We report the parallel contact limitation of our separate DA target-label reference.

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