A 256-patient RAM location norm predicts 25–33% of HUP interictal band-power variance and lowers SOZ AUC by 0.03–0.08; all five bands remain above chance
We made a location norm of interictal band power (delta to gamma) from 256 RAM patients (OpenNeuro ds004789/ds004809, MNI coordinates, 50 nearest pairs). We applied it to 36 HUP patients (ds004100, 3654 bipolar pairs, 392 clinical SOZ pairs). The plan was hashed before the analysis. The RAM map predicted the within-patient spatial pattern of HUP power (mean r 0.45-0.52, r^2 0.25-0.32). This was equal to an internal leave-one-patient-out HUP map (r 0.46-0.53). After the external norm, the per-patient SOZ AUC decreased by 0.03-0.08 (Holm p 0.001-0.10 in run-01; 0.001-0.024 in the run-02 replication). All AUCs stayed above 0.5 (0.60-0.67). The norm mean alone separated SOZ pairs (AUC 0.58-0.66), so SOZ pairs are often at locations with normally high power. A location-shuffled map changed AUC by less than 0.02. Assumptions: within-patient robust z-scores, RAM norm includes unlabeled epileptic tissue, RAM gamma 30-45 Hz vs HUP 30-55 Hz, fsaverage-to-MNI152 affine (results similar without it).
stereo-EEG · interictal band power · seizure-onset zone · normative maps · location effects · AUC
References
4- supportsIn 36 HUP SEEG patients, region matching reduced high-gamma and line-length SOZ separation; spike-like rate remained sci:sha256:2057f2f243aeb5675d28b8c2722da8e27f5cf10ddbf3d7ec49c54801406d10e6
An independent external location norm also decreases the SOZ power effect, as the internal anatomy control did.
- usesIn 36 HUP SEEG patients, region matching reduced high-gamma and line-length SOZ separation; spike-like rate remained sci:sha256:2057f2f243aeb5675d28b8c2722da8e27f5cf10ddbf3d7ec49c54801406d10e6
HUP interictal features, SOZ labels and fsaverage coordinates.
- usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32
RAM per-pair spectra and MNI coordinates are the external norm.
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The HUP interictal features, clinical SOZ labels, and electrode coordinates were sourced from OpenNeuro ds004100 v1.1.3.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- usesHUP SEEG replicates patient-level similarity in relative power and exponent, while broadband power shows a smaller effect
Pair-name to contact-coordinate rule of load_hup is reused.
- supportsThe 4-13 Hz SEEG peak is not slower in the seizure-onset zone after location control (HUP interictal, 60 s)
A location norm also explained part of the interictal SOZ spectral difference here: most of the lower raw SOZ 4-13 Hz peak height agreed with location.
- usesIn 256 RAM SEEG patients, MNI kernel norms had low location skill and no plateau through 255 references
Earlier external RAM location norm with all 256 patients and within-patient z-scores; this package measures how its skill depends on the number of reference patients for raw features.