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q-bio.NC · Neurons and Cognition

The 4-13 Hz SEEG peak is not slower in the seizure-onset zone after location control (HUP interictal, 60 s)

We tested if the 4-13 Hz spectral peak is slower at clinical seizure-onset-zone (SOZ) SEEG pairs than at other pairs of the same patient. We used archived 60-s interictal bipolar spectra (5b3e64dc), clinical SOZ labels (5ec6e903, f2d12890) and fsaverage coordinates (ds004100). The plan was hashed before the analysis. For each pair, a location norm was the median of the 20 nearest non-SOZ pairs of other HUP patients. Primary result (HUP, n = 30): location-adjusted SOZ minus non-SOZ peak frequency +0.30 Hz (95% CI -0.40 to +1.05, sign-flip p 0.43). Raw peak frequency in both cohorts (n = 38): +0.26 Hz (p 0.42). Peak height and peak presence did not differ after Holm correction. Descriptive: raw SOZ peak height was lower in HUP (-0.106 log10, p 0.001), but the location norm was also lower at SOZ pairs (-0.084), and the adjusted difference was -0.017 (p 0.56). Limits: 60 s, unknown vigilance state, template coordinates, a weak norm for peak frequency (r 0.17).

stereo-EEG · seizure-onset zone · spectral peak · interictal · epilepsy · location adjustment

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References

9
  1. usesAcross 60 interictal SEEG patients, SOZ pairs had lower beta and alpha power shares; alpha differed by cohort sci:sha256:df9f11bc8ea45b8668efc93989d25a91b03b9087eb56386d50ae491fc2a777af

    Copies of the per-pair clinical SOZ label tables of 5ec6e903 and f2d12890.

  2. usesAdult interictal SEEG did not significantly replicate the RAM age association with peak height sci:sha256:9f0ed8b839589c562033e683eff432018443b657e9ae2b777a9348d7489b58e4

    Per-pair 60-s interictal bipolar spectra, accept flags and peak code are the input.

  3. supportsA 256-patient RAM location norm predicts 25–33% of HUP interictal band-power variance and lowers SOZ AUC by 0.03–0.08; all five bands remain above chance sci:sha256:a7b5f76787c7d98192ffc53e2f2c2d12192931382c8e0a5eed5169c6bd9e4fa8

    A location norm also explained part of the interictal SOZ spectral difference here: most of the lower raw SOZ 4-13 Hz peak height agreed with location.

  4. usesThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615

    Source of the ds004100 per-pair SOZ labels.

  5. usesIn 25 HUP patients, interictal 2–13 Hz SEEG peaks did not replicate the medial–lateral difference after Holm correction sci:sha256:88e96337c3b30685e748b6f6d26f189f265034f3d76b418650f1028294ba71f6

    Archived ds004100 fsaverage electrodes.tsv files for the location norm.

  6. usesAcross 29 SEEG patients, the 30–45 Hz exponent did not separate SOZ channels, while four other features did sci:sha256:115bc8cb0b4c9e536b5f083843a2745508d3c6635a8156b661a9e084f51582a7

    Source of the ds003876 per-pair SOZ labels.

  7. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    Source dataset for the HUP interictal spectra, clinical seizure-onset-zone labels, and fsaverage contact coordinates used in this analysis.

  8. usesdoi:10.18112/openneuro.ds003876.v1.0.2

    Source dataset for the ds003876 interictal spectra and clinical seizure-onset-zone labels used in the raw, two-cohort comparison.

  9. doi:10.1101/2021.10.15.464594

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