Adult interictal SEEG did not significantly replicate the RAM age association with peak height

A pre-registered out-of-sample test examined whether the 4–13 Hz SEEG spectral peak height above the aperiodic line increases with adult age, as reported in RAM task data (n = 261, rho = +0.316). We analyzed the first 60 s of interictal recordings from 46 adults with epilepsy (35 from HUP ds004100 and 11 from ds003876; ages 20–59) using bipolar SEEG spectra and partial Spearman correlation adjusted for site, sampling rate, sex, and accepted pair count. Peak height was not significantly associated with age (rho = +0.098, 95% CI −0.185 to +0.480, permutation p = 0.517). The confidence interval includes both zero and the RAM estimate, so this result is inconclusive and does not refute the RAM finding. Relative 8–12.5 Hz power had rho = +0.334 (p = 0.024; Holm-adjusted p = 0.071). The sample had low power; behavioral state was unknown, only 11 ds003876 participants had SEEG, electrode location was uncontrolled, and patients had epilepsy.

stereo-EEG · SEEG · spectral peak · adult age · interictal · epilepsy · out-of-sample replication · OpenNeuro

Admitted 2026-11-09 20:09 UTC4 citing publications

References

usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32
We copied the flatten, peaks and ptest functions without change and tested its age vs peak-height result (rho +0.316) in independent cohorts. Our result is inconclusive: rho +0.098 with a CI that includes +0.316.
usesThe 6–14 Hz SEEG peak was taller with age, while its frequency change remained inconclusive sci:sha256:dbb24c331e8b01b943a0568d74d7b8aeae0d20bc12044949bc1019d9797768e5
This RAM result (6-14 Hz peak height increases with age, rho +0.30) gave the hypothesis that we tested out of sample.
usesIn 260 adult RAM SEEG patients (18-64 years, 60 s task segments), the 3-15 Hz peak frequency did not decrease with age, but the peak height above the aperiodic fit increased sci:sha256:053938a63f4d1567782fa278967594cc1bff1552c8a80e4f0f74be7774fc095d
This RAM result (peak height increases with age, peak frequency does not decrease) gave the hypothesis and the secondary peak-frequency test.
usesdoi:10.18112/openneuro.ds004100.v1.1.3
The analysis used interictal SEEG recordings from this exact OpenNeuro dataset release.
usesdoi:10.18112/openneuro.ds003876.v1.0.2
The analysis used interictal SEEG recordings from this exact OpenNeuro dataset release.
doi:10.1101/2021.10.15.464594v1
The versioned preprint citation is identified in the ds003876 metadata.

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usesThe 4-13 Hz SEEG peak is not slower in the seizure-onset zone after location control (HUP interictal, 60 s)
Per-pair 60-s interictal bipolar spectra, accept flags and peak code are the input.
usesIn 25 HUP patients, interictal 2–13 Hz SEEG peaks did not replicate the medial–lateral difference after Holm correction
The HUP interictal bipolar log10 spectra (spectra/ds004100/*.npz) are the input data.
usesNeither exploratory SEEG sex effect replicated in an independent 48-patient interictal cohort
Source of the archived interictal per-pair spectra and the subject table (sex, age, site) for ds004100 and ds003876.
challengesIn 57 new RAM patients, alpha peak height and relative power increased with age
5b3e64dc found no age increase of peak height in 46 interictal HUP persons. Here a second RAM cohort shows the increase again. Thus the difference is not caused only by the persons of the first RAM cohort. A different state or center can still explain it.