The 6–14 Hz SEEG peak was taller with age, while its frequency change remained inconclusive

A pre-registered analysis tested whether the 6–14 Hz spectral peak in bipolar stereoelectroencephalography (SEEG) was lower in older adults with epilepsy. It used the same 60 s word-encoding segments and accepted bipolar pairs as an earlier analysis of OpenNeuro datasets ds004789 and ds004809, and recomputed Welch spectra at 0.5 Hz resolution. The fetch stopped at the planned 18 min limit after 116 of 261 patients had been processed in shuffled order (seed 20261011). For all 116, EDF chunk, TSV, header, and accepted-pair-mask hashes matched the earlier analysis. Partial Spearman correlations adjusted for site, sampling rate, sex, log number of accepted pairs, and dataset; confidence intervals used 5,000 patient bootstrap samples, p-values used 10,000 permutations, and Holm correction covered four tests. Peak frequency was not significantly associated with age (n=114, rho=-0.137, 95% CI -0.332 to 0.072, Holm p=0.42); the confidence interval did not exclude an effect of magnitude 0.2, so the result is inconclusive. Peak height increased with age (n=114, rho=+0.299, 95% CI +0.115 to +0.473, Holm p=0.004). The 7–13 Hz centre of gravity and fraction of pairs with a peak were not significantly associated with age. A slowing of about 0.2 Hz per decade remains possible but was not shown. The study is limited to epilepsy patients, one eyes-open encoding segment per patient, unequal implant locations without regional matching, a partial random subset, and no older adults. The source report gives ages 18–58 for the fetched sample and 18–64 elsewhere.

stereoelectroencephalography · SEEG · alpha peak frequency · peak height · aging · epilepsy · Welch spectrum · OpenNeuro