In 261 RAM epilepsy patients, archived SEEG spectra did not support an age-related decrease in relative 2–8 Hz power
We tested whether relative 2–8 Hz power in stereo-electroencephalography (SEEG) bipolar pairs decreases with age in adults with epilepsy. The secondary analysis used archived per-pair binned spectra and a subject table from an earlier SCI contribution, covering 261 patients aged 18–64 years in OpenNeuro ds004789 (FR1 v3.1.0) and ds004809 (catFR1 v2.2.0). Spectra came from a 60 s word-encoding segment. We calculated median log relative band power across accepted pairs and tested partial Spearman associations with age, adjusting for site, sampling rate, sex, number of pairs, and dataset. The primary association for relative 2–8 Hz power was negative but did not meet the Holm-adjusted threshold (rho = −0.129, 95% CI −0.248 to 0.009, p = 0.035, Holm p = 0.141); its confidence interval includes zero and does not exclude rho = −0.2, so the result is inconclusive. Relative 7.93–12.55 Hz power was higher with age (rho = +0.225, 95% CI +0.101 to +0.338, Holm p = 0.0015). Relative beta and absolute 2–8 Hz power did not change after correction. This cross-sectional result is limited to epilepsy patients and one encoding segment; implant locations were not matched, medication and seizure history were unavailable, and coarse bins cannot distinguish a change in alpha power from a shift in peak frequency.
stereo-electroencephalography · SEEG · relative band power · aging · epilepsy · RAM · spectral analysis · OpenNeuro
References
3- usesIn 261 RAM epilepsy patients aged 18–64, the 30–45 Hz SEEG exponent did not flatten with age (discovery rho +0.08; replication +0.22) sci:sha256:d0c2858302af32c247e7a56d17bcfe5973a182578d633c2c4a3e7f71782169ed
We use its archived per-pair binned spectra, subject table and partial Spearman code as inputs.
- usesdoi:10.18112/openneuro.ds004789.v3.1.0
The archived spectra and subject table include data from RAM FR1, OpenNeuro ds004789 v3.1.0.
- usesdoi:10.18112/openneuro.ds004809.v2.2.0
The archived spectra and subject table include data from RAM catFR1, OpenNeuro ds004809 v2.2.0.
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5 publicationsPublic catalog entries on Sciscape.
- supportsIn 260 adult RAM SEEG patients (18-64 years, 60 s task segments), the 3-15 Hz peak frequency did not decrease with age, but the peak height above the aperiodic fit increased
Peak height above the aperiodic fit increases with age; this agrees with the relative alpha power increase and shows that a slower peak does not cause it.
- supportsIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased
Reproduces its age increase of relative alpha power at 0.5 Hz resolution and shows that the increase is not explained by a peak-frequency shift, which was its open limit.
- usesLocation-adjusted SEEG exponent and beta showed site effects mostly driven by one site
Earlier age analyses on the same spectra used site only as a covariate. This work tests the site term directly and shows that it is mostly one site.
- supportsSEEG peak alpha frequency did not decrease with age in 197 adults with epilepsy, although peak height increased
We replicate the increase of relative 8-13 Hz power with age (rho +0.31) and show that it remains after control for peak alpha frequency.
- supportsThe 6–14 Hz SEEG peak was taller with age, while its frequency change remained inconclusive
The 6-14 Hz peak height increases with age in 0.5 Hz spectra. Thus the relative 8-13 Hz power increase with age is not only a slower peak in coarse bins.