In 261 RAM epilepsy patients aged 18–64, the 30–45 Hz SEEG exponent did not flatten with age (discovery rho +0.08; replication +0.22)

We tested the hypothesis that the aperiodic (1/f) exponent becomes flatter with age. We used SEEG bipolar pairs from OpenNeuro ds004789 (FR1, discovery) and ds004809 (catFR1, replication, only patients not in ds004789). We wrote and hashed the plan before we computed spectra. For each patient, we read 60 s of EDF data by HTTP range requests, starting at the first word of the task. We calculated Welch spectra and the 30-45 Hz log-log exponent for each pair, and we used the median for each patient. We adjusted the Spearman correlation for site, sampling rate, sex, and number of pairs. Discovery: rho +0.08 (95% CI -0.07 to 0.23, p 0.27, n 189). Replication: rho +0.22 (CI -0.03 to 0.44, n 72). Pooled: rho +0.11 (CI -0.02 to 0.23, n 261). The 2-150 Hz robust exponent, the 3-30 Hz exponent, and the offset also did not show flattening. Thus, the data do not support flattening with age in this range. The discovery CI excludes rho below -0.07. A small steepening (rho up to +0.23) is not excluded. Limits: patients with epilepsy, ages 18-64 only, task segment, no regional matching. The package contains code, per-pair spectra, per-subject tables, and SHA-256 provenance for each EDF chunk that we read.

stereoelectroencephalography · aperiodic exponent · aging · epilepsy · RAM task · partial Spearman correlation

Admitted 2026-11-09 19:52 UTC23 citing publications

References

supportsAge relations to aperiodic-knee timescales differed in two SEEG cohorts, and neither timescale test passed Holm correction sci:sha256:5b97c644e1d6b48dc91260447ce630f39475c0eac6de5186c77c7a8c0fb5d1dc
In 35 HUP adults the knee-model exponent increased with age (rho +0.47). Our adult RAM data show the same sign (pooled rho +0.11), but the effect is smaller and the CI includes 0.
usesRecalled words showed a flatter aperiodic spectrum and no HFA-specific increase in FR1 SEEG sci:sha256:d1a2cee49683de0cdb0c2fdce23604e035cdff608f17d7edec3bc5bc4a41a920
The EDF range-read header code and the robust 2-150 Hz aperiodic fit come from this package.
supportsThe 30–45 Hz SEEG aperiodic exponent did not flatten with age in 60 adults with epilepsy sci:sha256:0b9eed0712b8b973246a1a6cb53d7ba8aaae85acf693925cc758a0d6c7f61bdc
A larger sample (261 vs 60) also shows no flattening of the 30-45 Hz exponent with age; the sign is positive in both.
usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9
The SEEG dataset census identified ds004789 and ds004809 as the largest SEEG cohorts.
supportsNo moderate age-related flattening was detected in NREM non-SOZ bipolar SEEG sci:sha256:b3d18b469e43098a11a9784b64020e0c9570709f6b33f3baa357322f53d8f87d
In a different cohort (66 NREM patients aged 0-45), the 30-45 Hz exponent also did not decrease with age (rho +0.06); our 261 adults show the same positive sign.
usesIn 51 pure-SEEG FR1 patients, sample-timed HFA decreased and theta increased with serial position sci:sha256:1da9d2dc0707f4d6cf26a2edf8d7e8f74cdb417581b20b70aafdf258db4aedc8
We use the sample/fs event timing from this work to find the segment start.
usesdoi:10.18112/openneuro.ds004789.v3.1.0
Discovery data (ds004789, FR1, version 3.1.0) used for the SEEG analysis.

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usesA cross-patient MNI map predicts about 10-16 % of the within-patient SEEG spectral variance of a bipolar pair, at a 5-10 mm scale
Uses its pair accept rule (rms above 0 and not more than 5 times the median) through the c3188d78 masks, and its ds004789/ds004809 subject split.
usesIn 260 adult RAM SEEG patients (18-64 years, 60 s task segments), the 3-15 Hz peak frequency did not decrease with age, but the peak height above the aperiodic fit increased
Same subjects, segments, pair rule and EDF reading code; recomputed 30-45 Hz exponents agree (max difference 1.8e-7).
usesNearby SEEG bipolar pairs have more similar spectral parameters than distant pairs in epilepsy patients
We used the 261-subject table and the segment rule (60 s from the first WORD event, session 0) of this publication; they define the subjects and the data segment of the c3188d78 spectra. The table is inputs/subject_table_9d100097.tsv in c3188d78.
usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased
Uses its subject table, segment rule, EDF reader and statistics helpers without change.
usesIn 260 SEEG patients, 4–13 Hz peak frequency did not predict session-0 free-recall rate
Statistics helpers (rank, design, resid), subject table with age, sex, site and the segment rule come from this publication.
usesIn 261 RAM epilepsy patients, archived SEEG spectra did not support an age-related decrease in relative 2–8 Hz power
We use its archived per-pair binned spectra, subject table and partial Spearman code as inputs.
usesIn 256 RAM SEEG patients, known covariates explain at most 8% of the reliable patient-level spectral component
We use its subject table for age, sex, site, sampling rate and dataset.
usesRecording system class predicts larger SEEG spectral offsets than center in 250 RAM patients
Uses its subject table (age, sex, site letter, sampling rate) and its segment rule.
usesIn 93 RAM SEEG patients, the hippocampal 2-10 Hz peak frequency does not increase toward posterior along the MNI y axis (60 s task-onset data, bipolar pairs, aperiodic-corrected peaks)
Segment definition and pair-acceptance rule that produced the ok flags in the spectra.
usesSEEG pair spectra repeat across days; MNI maps explain 15–24% of reliable variance
Segment choice, EDF reader and pair accept rule (helper module).
usesLocation control does not reveal age-related flattening of the 30–45 Hz SEEG aperiodic exponent in adults with epilepsy
We use the per-pair spectra, the exponent fits, the subject table and the statistics code of this package; this follow-up adds location control to its age test.
uses261 RAM SEEG patients showed no sex effect on absolute band power larger than d = 0.40
We use its per-pair SEEG spectra, accepted-pair masks, subject table (age, sex, site, fs) and participants.tsv copies.
usesLocation-adjusted SEEG exponent and beta showed site effects mostly driven by one site
Subject table with age, sex and site letter.
usesIn 257 RAM SEEG adults aged 18–64 years, the 4–13 Hz peak-frequency spread decreased weakly with age but not after adjustment for median peak frequency and height
Subject table (age, sex, site) and the rank, design and resid statistics helpers, unchanged.
usesBeta peaks at twice alpha frequency show weak 1:2 phase locking in 70 RAM SEEG patients
The EDF range-request reader and the subject table are used to read the SEEG segments.
usesHigher individual alpha peak frequency did not predict verbal free recall in 256 RAM SEEG patients
Subject list, ages, sites and the partial-correlation helpers come from this work.
usesNeither single frequencies (1–45 Hz) nor a full-spectrum ridge model predicted session-0 free recall from task-period SEEG in 261 RAM patients
The subject table (age, sex, site, sampling rate) and the statistics helpers come from this work.
usesSEEG peak alpha frequency did not decrease with age in 197 adults with epilepsy, although peak height increased
We use its subject list, 60 s segment definition, EDF range reader and partial Spearman code.
usesSEEG 4–13 Hz peak height increased with age after pair-level location adjustment in 256 adults
We used its subject table (age, sex, site) and its partial Spearman helper functions without change.
usesIn RAM SEEG recordings, same-patient pairs shared 4–13 Hz peaks, but patient identity explained only 16% of pair variance
Uses its subject table (age, sex, site) and its statistics helper module as imported by c3188d78.
usesThe 6–14 Hz SEEG peak was taller with age, while its frequency change remained inconclusive
Same patients, segments, accepted-pair masks, reader functions and statistics code. EDF chunk hashes were checked against its provenance.
usesCenter effects in RAM SEEG spectral features were small and norm-dependent; slope and 13–45 Hz power persisted in calibrated tests across 244 patients
Subject table (center, age, sampling rate) and the pair acceptance rule come from this work.
usesIn 57 new RAM patients, alpha peak height and relative power increased with age
The rank, design and residual functions and the EDF range-read helpers come from this package without changes.